DegronMD - Q8IWT3(CUL9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E926Q	TCGA-86-8278	LUAD	TCGA	NRYSEPP	CBL_PTK	922:928	Mutation altering degron motif	0.5633
p.R586Q	TCGA-AP-A056	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.R586Q	TCGA-F5-6814	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.R586Q	DO36556	READ	ICGC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.R586Q	DO43971	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.25
p.R914H	TCGA-B5-A3FC	UCEC	TCGA	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1111
p.R914H	DO230335	COCA	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1111
p.R914H	DO230342	COCA	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1111
p.R914H	DO10806	EOPC	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1111
p.R914H	DO41871	UCEC	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1111
p.E578K	TCGA-BT-A20T	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.E578K	DO804	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.L917F	TCGA-EE-A2M5	SKCM	TCGA	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1944
p.M919V	TCGA-FI-A2D5	UCEC	TCGA	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.25
p.M919V	DO41331	UCEC	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.25
p.E937K	TCGA-ZJ-AAXU	CESC	TCGA	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.0833
p.E937K	DO219759	CESC	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.0833
p.M918V	DO49661	LIAD	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.2222
p.M918V	DO22830	LICA	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.2222
p.R933L	DO229037	LICA	ICGC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1944
p.R923C	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	NRYSEPP	CBL_PTK	922:928	Mutation altering degron motif	0.719
p.R923C	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	NRYSEPP	CBL_PTK	922:928	Mutation altering degron motif	0.719
p.P592L	SIDM00992	Thyroid Gland Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.P592L	ACH-000456	Thyroid Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.P592L	BCPAP	thyroid	COSMIC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.T584N	SIDM00282	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.T584N	ACH-000998	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.T584N	CW-2	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.3056
p.R933H	SIDM01473	Plasma Cell Myeloma	GDSC	NRYSEPP	CBL_PTK	922:928	Mutation rewiring degron network	0.1944

Kaplan plot for CUL9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CUL9

UniProt ID: Q8IWT3

Entrez ID: 23113

Protein name: Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CUL9 in