DegronMD

Uniprot ID: Q8IWT3

Source protein: Cullin-9

Source gene: CUL9

Class: CBL_PTK

Location: 922:928

E3 ligase: CBL

DEGRON score: 0.8984

ASA_SCORE: 74.0286

COIL: 0.7934

CONS_SCORE: 0.4233

DSS_SCORE: 0.5119

HELIX: 0.1863

FCONS_SCORE: 0.9406

RIG_SCORE: 0.6805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E926Q	TCGA-86-8278	LUAD	TCGA	NRYSEPP	CBL_PTK	0.5633
p.R914H	TCGA-B5-A3FC	UCEC	TCGA	NRYSEPP	CBL_PTK	0.1111
p.R914H	DO230335	COCA	ICGC	NRYSEPP	CBL_PTK	0.1111
p.R914H	DO230342	COCA	ICGC	NRYSEPP	CBL_PTK	0.1111
p.R914H	DO10806	EOPC	ICGC	NRYSEPP	CBL_PTK	0.1111
p.R914H	DO41871	UCEC	ICGC	NRYSEPP	CBL_PTK	0.1111
p.L917F	TCGA-EE-A2M5	SKCM	TCGA	NRYSEPP	CBL_PTK	0.1944
p.M919V	TCGA-FI-A2D5	UCEC	TCGA	NRYSEPP	CBL_PTK	0.25
p.M919V	DO41331	UCEC	ICGC	NRYSEPP	CBL_PTK	0.25
p.E937K	TCGA-ZJ-AAXU	CESC	TCGA	NRYSEPP	CBL_PTK	0.0833
p.E937K	DO219759	CESC	ICGC	NRYSEPP	CBL_PTK	0.0833
p.M918V	DO49661	LIAD	ICGC	NRYSEPP	CBL_PTK	0.2222
p.M918V	DO22830	LICA	ICGC	NRYSEPP	CBL_PTK	0.2222
p.R933L	DO229037	LICA	ICGC	NRYSEPP	CBL_PTK	0.1944
p.R923C	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	NRYSEPP	CBL_PTK	0.719
p.R923C	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	NRYSEPP	CBL_PTK	0.719
p.R933H	SIDM01473	Plasma Cell Myeloma	GDSC	NRYSEPP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWT3	Cullin-9	CBL_PTK	922:928	NRYSEPP	CBL	0.8984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons