DegronMD - Q9NRC6(SPTBN5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1298W	TCGA-05-4390	LUAD	TCGA	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.0833
p.R1298W	DO23562	LUAD	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.0833
p.P3553S	TCGA-5B-A90C	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation altering degron motif	0.6752
p.P3553S	DO219764	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation altering degron motif	0.6752
p.D2546N	TCGA-BR-8678	STAD	TCGA	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation rewiring degron network	0.3056
p.D2546N	DO47957	STAD	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation rewiring degron network	0.3056
p.G3549D	TCGA-DU-6407	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.2222
p.G3549D	DO22295	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.2222
p.G3567D	TCGA-E6-A1M0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.0556
p.G3567D	DO222492	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.0556
p.G3567D	DO43682	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.0556
p.Q1300H	TCGA-WA-A7GZ	HNSC	TCGA	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1389
p.Q1300H	DO219094	HNSC	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1389
p.L1310F	TCGA-YC-A9TC	BLCA	TCGA	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation altering degron motif	0.587
p.L1310F	DO51949	BLCA	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation altering degron motif	0.587
p.N3564T	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1389
p.N3564T	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1389
p.N3564T	DO229005	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1389
p.N3564T	DO52365	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1389
p.N3564T	DO231007	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1389
p.A2539E	DO229045	LICA	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation rewiring degron network	0.1111
p.S2559R	DO229006	LICA	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation rewiring degron network	0.2222
p.S2545F	DO229462	SKCA	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation rewiring degron network	0.2778
p.P3548S	DO229272	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1944
p.S1313P	DO229234	THCA	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation altering degron motif	0.5641
p.E2562K	SIDM00396	Acute Myeloid Leukemia	GDSC	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation rewiring degron network	0.1389
p.R3551T	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.2778
p.R3551T	RERF-LC-Sq1	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.2778
p.Q1317H	SIDM01018	Hodgkin's Lymphoma	GDSC	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.2778
p.Q1317H	KM-H2	haematopoietic and lymphoid tissue	COSMIC	RRQLLASLQ	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.2778
p.C3561Y	ACH-000939	Sarcoma	CCLE	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.2222
p.Q2549R	ACH-000988	Endometrial/Uterine Cancer	CCLE	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation altering degron motif	0.6218
p.Q2549R	MFE-319	endometrium	COSMIC	IRQVLAGLE	DEG_APCC_DBOX_1	2547:2555	Mutation altering degron motif	0.6218
p.P3548L	ACH-001688	Kidney Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	3553:3557	Mutation rewiring degron network	0.1944

Kaplan plot for SPTBN5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPTBN5

UniProt ID: Q9NRC6

Entrez ID: 51332

Protein name: Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPTBN5 in