DegronMD

Uniprot ID: Q9NRC6

Source protein: Spectrin beta chain, non-erythrocytic 5

Source gene: SPTBN5

Class: DEG_APCC_DBOX_1

Location: 1307:1315

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9214

ASA_SCORE: 77.6222

COIL: 0.0042

CONS_SCORE: 0.5444

DSS_SCORE: 0.2693

HELIX: 0.9957

FCONS_SCORE: 1.3222

RIG_SCORE: 0.7985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1298W	TCGA-05-4390	LUAD	TCGA	RRQLLASLQ	DEG_APCC_DBOX_1	0.0833
p.R1298W	DO23562	LUAD	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	0.0833
p.Q1300H	TCGA-WA-A7GZ	HNSC	TCGA	RRQLLASLQ	DEG_APCC_DBOX_1	0.1389
p.Q1300H	DO219094	HNSC	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	0.1389
p.L1310F	TCGA-YC-A9TC	BLCA	TCGA	RRQLLASLQ	DEG_APCC_DBOX_1	0.587
p.L1310F	DO51949	BLCA	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	0.587
p.S1313P	DO229234	THCA	ICGC	RRQLLASLQ	DEG_APCC_DBOX_1	0.5641
p.Q1317H	SIDM01018	Hodgkin's Lymphoma	GDSC	RRQLLASLQ	DEG_APCC_DBOX_1	0.2778
p.Q1317H	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	RRQLLASLQ	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRC6	Spectrin beta chain, non-erythrocytic 5	DEG_APCC_DBOX_1	1307:1315	RRQLLASLQ	APC,CDC20,FZR1	0.9214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons