DegronMD

Uniprot ID: Q9NRC6

Source protein: Spectrin beta chain, non-erythrocytic 5

Source gene: SPTBN5

Class: DEG_APCC_DBOX_1

Location: 2547:2555

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6532

ASA_SCORE: 54.7889

COIL: 0.0041

CONS_SCORE: 0.4574

DSS_SCORE: 0.2579

HELIX: 0.9957

FCONS_SCORE: 1.1939

RIG_SCORE: 0.7862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2546N	TCGA-BR-8678	STAD	TCGA	IRQVLAGLE	DEG_APCC_DBOX_1	0.3056
p.D2546N	DO47957	STAD	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	0.3056
p.A2539E	DO229045	LICA	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	0.1111
p.S2559R	DO229006	LICA	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	0.2222
p.S2545F	DO229462	SKCA	ICGC	IRQVLAGLE	DEG_APCC_DBOX_1	0.2778
p.E2562K	SIDM00396	Acute Myeloid Leukemia	GDSC	IRQVLAGLE	DEG_APCC_DBOX_1	0.1389
p.Q2549R	ACH-000988	Endometrial/Uterine Cancer	CCLE	IRQVLAGLE	DEG_APCC_DBOX_1	0.6218
p.Q2549R	MFE-319	endometrium	COSMIC	IRQVLAGLE	DEG_APCC_DBOX_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRC6	Spectrin beta chain, non-erythrocytic 5	DEG_APCC_DBOX_1	2547:2555	IRQVLAGLE	APC,CDC20,FZR1	0.6532	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons