DegronMD - O15481(MAGEB4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T328A	TCGA-17-Z021	LUAD	TCGA	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0833
p.A73T	TCGA-27-1833	GBM	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.A73T	DO12976	GBM	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.A74V	TCGA-44-7670	LUAD	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.A74V	DO23555	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.A74V	DO229100	UTCA	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.A33E	TCGA-55-7995	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33E	DO45323	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A97D	TCGA-55-8511	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7793
p.A97D	DO24940	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.7793
p.A32E	TCGA-56-8307	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.A32E	DO219139	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.P30T	TCGA-78-7220	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.P30T	DO24409	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.S108F	TCGA-86-A4JF	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1389
p.S108F	DO45317	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1389
p.D48N	TCGA-91-6831	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.D48N	DO23753	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.S70Y	TCGA-AJ-A5DW	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.8231
p.S70Y	DO50075	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.8231
p.F56S	TCGA-AN-A046	BRCA	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.F56S	DO1285	BRCA	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.S53Y	TCGA-AP-A056	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.S53Y	DO43971	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0556
p.S52N	TCGA-AP-A1DV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.S52N	DO43186	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.A33T	TCGA-BS-A0UV	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.A33T	DO42793	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1667
p.T327I	TCGA-CV-7245	HNSC	TCGA	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0556
p.T327I	DO14322	HNSC	ICGC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.0556
p.A337T	TCGA-D3-A8GP	SKCM	TCGA	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7139
p.A337T	DO51244	SKCM	ICGC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7139
p.P30S	TCGA-D7-A6EY	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.P30S	DO50118	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.0833
p.M346I	TCGA-DU-6392	LGG	TCGA	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.M346I	DO22237	LGG	ICGC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1944
p.D48Y	TCGA-EE-A183	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.D48Y	DO37715	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.A333V	TCGA-EI-6507	READ	TCGA	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.A333V	DO36675	READ	ICGC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.2222
p.A71V	TCGA-EO-A22R	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.A71V	DO42713	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.G57D	TCGA-FI-A2D0	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.G57D	DO43891	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.S339F	TCGA-IN-8663	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7982
p.S339F	DO47805	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation altering degron motif	0.7982
p.P67T	TCGA-MI-A75I	LIHC	TCGA	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5919
p.P67T	DO49712	LIHC	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.5919
p.S94F	TCGA-ZJ-AAXU	CESC	TCGA	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.S94F	DO219759	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.25
p.S51C	TCGA-ZJ-AB0H	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1111
p.S51C	DO219760	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1111
p.S108P	DO225269	BRCA	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.1389
p.R103G	DO224910	BRCA	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.2778
p.T110I	DO50970	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.0833
p.T101I	DO231169	LUSC	ICGC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation altering degron motif	0.8189
p.E34K	DO220856	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1944
p.S80F	DO228017	SKCA	ICGC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.M330T	SIDM01144	Gastric Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00568	Gastric Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00619	Thyroid Gland Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00931	Thyroid Gland Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00024	Non-Cancerous	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00564	Ovarian Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00576	Acute Myeloid Leukemia	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM01217	Other Blood Cancers	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00543	Melanoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00861	Ovarian Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM00901	Endometrial Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM01335	Kidney Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM01726	Ewing's Sarcoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.M330T	SIDM01443	Gastric Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	337:341	Mutation rewiring degron network	0.1389
p.P66L	SIDM00899	Pancreatic Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7582
p.P66L	ACH-000222	Pancreatic Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7582
p.P66L	AsPC-1	pancreas	COSMIC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7582
p.G57V	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.G57V	ACH-000662	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.G57V	COR-L23	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.E102Q	SIDM00414	Bladder Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.3056
p.E102Q	ACH-000545	Bladder Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.3056
p.E102Q	VM-CUB-1	urinary tract	COSMIC	ASTST	DEG_SPOP_SBC_1	97:101	Mutation rewiring degron network	0.3056
p.Q60P	SIDM01612	Endometrial Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.A50G	SIDM01781	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389
p.A50G	ACH-000325	Gastric Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	39:43	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGEB4

UniProt ID: O15481

Entrez ID: 4115

Protein name: Melanoma-associated antigen B4 (MAGE-B4 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGEB4 in