DegronMD

Uniprot ID: O15481

Source protein: Melanoma-associated antigen B4

Source gene: MAGEB4

Class: DEG_SPOP_SBC_1

Location: 66:70

E3 ligase: SPOP

DEGRON score: 0.9159

ASA_SCORE: 65.16

COIL: 0.8948

CONS_SCORE: 0.2701

DSS_SCORE: 0.7618

HELIX: 0.0658

FCONS_SCORE: 0.9184

RIG_SCORE: 0.6365

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A73T	TCGA-27-1833	GBM	TCGA	PPTTS	DEG_SPOP_SBC_1	0.25
p.A73T	DO12976	GBM	ICGC	PPTTS	DEG_SPOP_SBC_1	0.25
p.A74V	TCGA-44-7670	LUAD	TCGA	PPTTS	DEG_SPOP_SBC_1	0.2222
p.A74V	DO23555	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.A74V	DO229100	UTCA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.S70Y	TCGA-AJ-A5DW	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	0.8231
p.S70Y	DO50075	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.8231
p.F56S	TCGA-AN-A046	BRCA	TCGA	PPTTS	DEG_SPOP_SBC_1	0.0556
p.F56S	DO1285	BRCA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.A71V	TCGA-EO-A22R	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	0.3056
p.A71V	DO42713	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.3056
p.G57D	TCGA-FI-A2D0	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	0.0833
p.G57D	DO43891	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.P67T	TCGA-MI-A75I	LIHC	TCGA	PPTTS	DEG_SPOP_SBC_1	0.5919
p.P67T	DO49712	LIHC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.5919
p.S80F	DO228017	SKCA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.P66L	SIDM00899	Pancreatic Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.7582
p.P66L	ACH-000222	Pancreatic Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.7582
p.P66L	AsPC-1	pancreas	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.7582
p.G57V	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.G57V	ACH-000662	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.0833
p.G57V	COR-L23	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.Q60P	SIDM01612	Endometrial Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	66:70	PPTTS	SPOP	0.9159	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	353:357	PPTTS	SPOP	0.8488	More...
P01106	Myc proto-oncogene protein	DEG_SPOP_SBC_1	245:249	PPTTS	SPOP	0.9673	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	400:404	PPTTS	SPOP	0.9764	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1492:1496	PPTTS	SPOP	0.7371	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3135:3139	PPTTS	SPOP	0.6836	More...
Q12857	Nuclear factor 1 A-type	DEG_SPOP_SBC_1	458:462	PPTTS	SPOP	0.9881	More...
Q16549	Proprotein convertase subtilisin/kexin type 7	DEG_SPOP_SBC_1	741:745	PPTTS	SPOP	0.9748	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	921:925	PPTTS	SPOP	0.9871	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	387:391	PPTTS	SPOP	0.9613	More...
Q86VF5	2-acylglycerol O-acyltransferase 3	DEG_SPOP_SBC_1	9:13	PPTTS	SPOP	0.9231	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	444:448	PPTTS	SPOP	0.9481	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	851:855	PPTTS	SPOP	0.9986	More...
Q96Q42	Alsin	DEG_SPOP_SBC_1	384:388	PPTTS	SPOP	0.957	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_SPOP_SBC_1	196:200	PPTTS	SPOP	0.9868	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	923:927	PPTTS	SPOP	0.6646	More...
A7MBM2	Protein dispatched homolog 2	DEG_SPOP_SBC_1	73:77	PPTTS	SPOP	0.8424	More...
O95755	Ras-related protein Rab-36	DEG_SPOP_SBC_1	21:25	PPTTS	SPOP	0.8571	More...
Q96LK8	Spermatogenesis-associated protein 32	DEG_SPOP_SBC_1	216:220	PPTTS	SPOP	0.7106	More...
Q8NC54	Keratinocyte-associated transmembrane protein 2	DEG_SPOP_SBC_1	89:93	PPTTS	SPOP	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTS

Degron related mutations and impact score

Drug responses associated with MAGEB4 mutations

All proteins holding degron of PPTTS