DegronMD - O95248(SBF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1230C	TCGA-17-Z062	LUAD	TCGA	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1944
p.A349T	TCGA-2W-A8YY	CESC	TCGA	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2222
p.A349T	DO223732	CESC	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2222
p.A349T	DO223019	ESCA	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2222
p.A349T	DO232761	PBCA	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2222
p.V1122L	TCGA-49-AARN	LUAD	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.0556
p.G784R	TCGA-AX-A1CI	UCEC	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation altering degron motif	0.7568
p.R1132H	TCGA-AX-A2HC	UCEC	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation altering degron motif	0.8244
p.L1239P	TCGA-B5-A5OC	UCEC	TCGA	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.7582
p.S773N	TCGA-BR-4361	STAD	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.0833
p.S1147C	TCGA-CN-4740	HNSC	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation substituting flanking lysine	0.25
p.A1234S	TCGA-CV-7177	HNSC	TCGA	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.3056
p.F350L	TCGA-D3-A8GM	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.25
p.F350L	DO50288	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.25
p.R1144Q	TCGA-DF-A2KN	UCEC	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation blocking phosphorylation signal	0.6667
p.E1148Q	TCGA-DK-A3IU	BLCA	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1111
p.P352L	TCGA-EA-A97N	CESC	TCGA	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.3056
p.P352L	DO49935	CESC	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.3056
p.P352L	DO33091	PACA	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.3056
p.A791T	TCGA-FI-A2D0	UCEC	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.3056
p.A791G	TCGA-FS-A4FC	SKCM	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.3056
p.K775R	TCGA-QH-A6CW	LGG	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.1389
p.R1124G	TCGA-QM-A5NM	UCS	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1111
p.E1149Q	DO612	BLCA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.0833
p.R1129C	DO229333	BTCA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.25
p.R1129C	DO233156	GACA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.25
p.A1126T	DO230326	COCA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.A792T	DO234302	ESAD	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.2778
p.A792T	DO43891	UCEC	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.2778
p.S1148C	DO14846	HNSC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1111
p.A1235S	DO14266	HNSC	ICGC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation altering degron motif	0.7588
p.K776R	DO50170	LGG	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation blocking ubiquitination signal	0.6111
p.K365M	DO228299	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1111
p.S775R	DO229019	LICA	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.1389
p.T355K	DO229035	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7306
p.S1148F	DO23228	LINC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1111
p.V1123L	DO218923	LUAD	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.0833
p.R781W	DO222696	MELA	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.3056
p.R1129H	DO35442	PACA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.25
p.A792G	DO37762	SKCM	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.2778
p.S774N	DO38887	STAD	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.1111
p.S358P	DO229253	THCA	ICGC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation blocking phosphorylation signal	0.75
p.R1145Q	DO223282	UCEC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1944
p.Q1225H	DO43186	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.0556
p.L1240P	DO52405	UCEC	ICGC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.3056
p.R1133H	DO41572	UCEC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation altering degron motif	0.8244
p.G785R	DO42544	UCEC	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation altering degron motif	0.6457
p.C1126F	SIDM00663	Melanoma	GDSC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.C1126F	ACH-000814	Skin Cancer	CCLE	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.C1126F	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.C1126R	SIDM00663	Melanoma	GDSC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.C1126R	ACH-000814	Skin Cancer	CCLE	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.C1126R	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1667
p.D772G	SIDM00660	Colorectal Carcinoma	GDSC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.0556
p.D772G	ACH-000985	Colon/Colorectal Cancer	CCLE	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.0556
p.D772G	LS-411N	large intestine	COSMIC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.0556
p.P1229T	SIDM00049	Colorectal Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.6111
p.P1229T	ACH-002233	Colon/Colorectal Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.6111
p.P1229T	DIFI	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation blocking phosphorylation signal	0.6111
p.E344A	SIDM01641	Non-Cancerous	GDSC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.R1132C	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation altering degron motif	0.8301
p.R1132C	ACH-000448	Lung Cancer	CCLE	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation altering degron motif	0.8301
p.R1132C	NCI-H1666	lung	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation altering degron motif	0.8301
p.P351A	SIDM00274	Gastric Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2778
p.P351A	ACH-000047	Gastric Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2778
p.P351A	GCIY	stomach	COSMIC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2778
p.E1242D	SIDM01611	Endometrial Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.25
p.E1242D	ACH-000996	Endometrial/Uterine Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.25
p.L1245P	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1667
p.L1245P	ACH-000925	Lung Cancer	CCLE	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1667
p.R1133C	NCI-H1666	lung	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation altering degron motif	0.8301
p.C1127F	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1944
p.P352A	GCIY	stomach	COSMIC	PPTTS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.3056
p.C1127R	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	1132:1140	Mutation rewiring degron network	0.1944
p.D773G	LS-411N	large intestine	COSMIC	ERAGLGDLE	DEG_APCC_DBOX_1	782:790	Mutation rewiring degron network	0.0833
p.P1230T	DIFI	large intestine	COSMIC	ADSSS	DEG_SPOP_SBC_1	1235:1239	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SBF1

UniProt ID: O95248

Entrez ID: 6305

Protein name: Myotubularin-related protein 5 (Inactive phosphatidylinositol 3-phosphatase 5) (SET-binding factor 1) (Sbf1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SBF1 in