DegronMD

Uniprot ID: O95248

Source protein: Myotubularin-related protein 5

Source gene: SBF1

Class: DEG_APCC_DBOX_1

Location: 1132:1140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9303

ASA_SCORE: 43.1222

COIL: 0.6946

CONS_SCORE: 0.4328

DSS_SCORE: 0.3013

HELIX: 0.2829

FCONS_SCORE: 1.0651

RIG_SCORE: 0.7565

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1122L	TCGA-49-AARN	LUAD	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	0.0556
p.R1132H	TCGA-AX-A2HC	UCEC	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	0.8244
p.S1147C	TCGA-CN-4740	HNSC	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	0.25
p.R1144Q	TCGA-DF-A2KN	UCEC	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	0.6667
p.E1148Q	TCGA-DK-A3IU	BLCA	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	0.1111
p.R1124G	TCGA-QM-A5NM	UCS	TCGA	QRLGLGTLS	DEG_APCC_DBOX_1	0.1111
p.E1149Q	DO612	BLCA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.0833
p.R1129C	DO229333	BTCA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.25
p.R1129C	DO233156	GACA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.25
p.A1126T	DO230326	COCA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.S1148C	DO14846	HNSC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1111
p.S1148F	DO23228	LINC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1111
p.V1123L	DO218923	LUAD	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.0833
p.R1129H	DO35442	PACA	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.25
p.R1145Q	DO223282	UCEC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1944
p.R1133H	DO41572	UCEC	ICGC	QRLGLGTLS	DEG_APCC_DBOX_1	0.8244
p.C1126F	SIDM00663	Melanoma	GDSC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.C1126F	ACH-000814	Skin Cancer	CCLE	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.C1126F	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.C1126R	SIDM00663	Melanoma	GDSC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.C1126R	ACH-000814	Skin Cancer	CCLE	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.C1126R	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1667
p.R1132C	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	QRLGLGTLS	DEG_APCC_DBOX_1	0.8301
p.R1132C	ACH-000448	Lung Cancer	CCLE	QRLGLGTLS	DEG_APCC_DBOX_1	0.8301
p.R1132C	NCI-H1666	lung	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	0.8301
p.R1133C	NCI-H1666	lung	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	0.8301
p.C1127F	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1944
p.C1127R	Hs939-T	skin	COSMIC	QRLGLGTLS	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRLGLGTLS

Degron related mutations and impact score

Drug responses associated with SBF1 mutations

All proteins holding degron of QRLGLGTLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95248	Myotubularin-related protein 5	DEG_APCC_DBOX_1	1132:1140	QRLGLGTLS	APC,CDC20,FZR1	0.9303	More...