DegronMD

Uniprot ID: O95248

Source protein: Myotubularin-related protein 5

Source gene: SBF1

Class: DEG_APCC_DBOX_1

Location: 782:790

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9429

ASA_SCORE: 89.3889

COIL: 0.7497

CONS_SCORE: 0.348

DSS_SCORE: 0.3511

HELIX: 0.1071

FCONS_SCORE: 0.8671

RIG_SCORE: 0.7151

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G784R	TCGA-AX-A1CI	UCEC	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	0.7568
p.G785R	DO42544	UCEC	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.6457
p.K776R	DO50170	LGG	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.6111
p.A791T	TCGA-FI-A2D0	UCEC	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	0.3056
p.A791G	TCGA-FS-A4FC	SKCM	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	0.3056
p.R781W	DO222696	MELA	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.3056
p.A792T	DO234302	ESAD	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.2778
p.A792T	DO43891	UCEC	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.2778
p.A792G	DO37762	SKCM	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.2778
p.K775R	TCGA-QH-A6CW	LGG	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	0.1389
p.S775R	DO229019	LICA	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.1389
p.S774N	DO38887	STAD	ICGC	ERAGLGDLE	DEG_APCC_DBOX_1	0.1111
p.S773N	TCGA-BR-4361	STAD	TCGA	ERAGLGDLE	DEG_APCC_DBOX_1	0.0833
p.D773G	LS-411N	large_intestine	COSMIC	ERAGLGDLE	DEG_APCC_DBOX_1	0.0833
p.D772G	SIDM00660	Colorectal Carcinoma	GDSC	ERAGLGDLE	DEG_APCC_DBOX_1	0.0556
p.D772G	ACH-000985	Colon/Colorectal Cancer	CCLE	ERAGLGDLE	DEG_APCC_DBOX_1	0.0556
p.D772G	LS-411N	large_intestine	COSMIC	ERAGLGDLE	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95248	Myotubularin-related protein 5	DEG_APCC_DBOX_1	782:790	ERAGLGDLE	APC,CDC20,FZR1	0.9429	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons