DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERAGLGDLE
Uniprot ID:
O95248
Source protein:
Myotubularin-related protein 5
Source gene:
SBF1
Class:
DEG_APCC_DBOX_1
Location:
782:790
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9429
ASA_SCORE:
89.3889
COIL:
0.7497
CONS_SCORE:
0.348
DSS_SCORE:
0.3511
HELIX:
0.1071
FCONS_SCORE:
0.8671
RIG_SCORE:
0.7151
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G784R
TCGA-AX-A1CI
UCEC
TCGA
ERAGLGDLE
DEG_APCC_DBOX_1
0.7568
p.S773N
TCGA-BR-4361
STAD
TCGA
ERAGLGDLE
DEG_APCC_DBOX_1
0.0833
p.A791T
TCGA-FI-A2D0
UCEC
TCGA
ERAGLGDLE
DEG_APCC_DBOX_1
0.3056
p.A791G
TCGA-FS-A4FC
SKCM
TCGA
ERAGLGDLE
DEG_APCC_DBOX_1
0.3056
p.K775R
TCGA-QH-A6CW
LGG
TCGA
ERAGLGDLE
DEG_APCC_DBOX_1
0.1389
p.A792T
DO234302
ESAD
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.2778
p.A792T
DO43891
UCEC
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.2778
p.K776R
DO50170
LGG
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.6111
p.S775R
DO229019
LICA
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.1389
p.R781W
DO222696
MELA
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.3056
p.A792G
DO37762
SKCM
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.2778
p.S774N
DO38887
STAD
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.1111
p.G785R
DO42544
UCEC
ICGC
ERAGLGDLE
DEG_APCC_DBOX_1
0.6457
p.D772G
SIDM00660
Colorectal Carcinoma
GDSC
ERAGLGDLE
DEG_APCC_DBOX_1
0.0556
p.D772G
ACH-000985
Colon/Colorectal Cancer
CCLE
ERAGLGDLE
DEG_APCC_DBOX_1
0.0556
p.D772G
LS-411N
large_intestine
COSMIC
ERAGLGDLE
DEG_APCC_DBOX_1
0.0556
p.D773G
LS-411N
large_intestine
COSMIC
ERAGLGDLE
DEG_APCC_DBOX_1
0.0833
Drug responses associated with SBF1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERAGLGDLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95248
Myotubularin-related protein 5
DEG_APCC_DBOX_1
782:790
ERAGLGDLE
APC,CDC20,FZR1
0.9429
More...