DegronMD

Uniprot ID: O95755

Source protein: Ras-related protein Rab-36

Source gene: RAB36

Class: DEG_SPOP_SBC_1

Location: 21:25

E3 ligase: SPOP

DEGRON score: 0.8571

ASA_SCORE: 72.6

COIL: 0.9238

CONS_SCORE: 0.1731

DSS_SCORE: 0.5931

HELIX: 0.0408

FCONS_SCORE: 1

RIG_SCORE: 0.7392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R28C	TCGA-34-5929	LUSC	TCGA	PPTTS	DEG_SPOP_SBC_1	0.25
p.R28C	DO26659	LUSC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.25
p.T26M	TCGA-DU-6392	LGG	TCGA	PPTTS	DEG_SPOP_SBC_1	0.75
p.T26M	DO22237	LGG	ICGC	PPTTS	DEG_SPOP_SBC_1	0.75
p.R12L	TCGA-P3-A6SX	HNSC	TCGA	PPTTS	DEG_SPOP_SBC_1	0.0833
p.R12L	DO49051	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.A14S	DO228985	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1389
p.V35L	DO229024	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.P22H	SIDM00120	Prostate Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.6583
p.P22H	ACH-000979	Prostate Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.6583
p.P22H	DU-145	prostate	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.6583
p.V35E	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.V35E	SIDM00112	Kidney Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.V35E	SIDM00241	Breast Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.V35E	SIDM00164	Biliary Tract Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.V35E	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	0.0556
p.T23M	SIDM01088	Endometrial Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.8534
p.T23M	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.8534
p.T23M	RL95-2	endometrium	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.8534
p.S16R	SIDM01451	Pancreatic Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.1944
p.S16R	ACH-000933	Pancreatic Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	66:70	PPTTS	SPOP	0.9159	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	353:357	PPTTS	SPOP	0.8488	More...
P01106	Myc proto-oncogene protein	DEG_SPOP_SBC_1	245:249	PPTTS	SPOP	0.9673	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	400:404	PPTTS	SPOP	0.9764	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1492:1496	PPTTS	SPOP	0.7371	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3135:3139	PPTTS	SPOP	0.6836	More...
Q12857	Nuclear factor 1 A-type	DEG_SPOP_SBC_1	458:462	PPTTS	SPOP	0.9881	More...
Q16549	Proprotein convertase subtilisin/kexin type 7	DEG_SPOP_SBC_1	741:745	PPTTS	SPOP	0.9748	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	921:925	PPTTS	SPOP	0.9871	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	387:391	PPTTS	SPOP	0.9613	More...
Q86VF5	2-acylglycerol O-acyltransferase 3	DEG_SPOP_SBC_1	9:13	PPTTS	SPOP	0.9231	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	444:448	PPTTS	SPOP	0.9481	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	851:855	PPTTS	SPOP	0.9986	More...
Q96Q42	Alsin	DEG_SPOP_SBC_1	384:388	PPTTS	SPOP	0.957	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_SPOP_SBC_1	196:200	PPTTS	SPOP	0.9868	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	923:927	PPTTS	SPOP	0.6646	More...
A7MBM2	Protein dispatched homolog 2	DEG_SPOP_SBC_1	73:77	PPTTS	SPOP	0.8424	More...
O95755	Ras-related protein Rab-36	DEG_SPOP_SBC_1	21:25	PPTTS	SPOP	0.8571	More...
Q96LK8	Spermatogenesis-associated protein 32	DEG_SPOP_SBC_1	216:220	PPTTS	SPOP	0.7106	More...
Q8NC54	Keratinocyte-associated transmembrane protein 2	DEG_SPOP_SBC_1	89:93	PPTTS	SPOP	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTS

Degron related mutations and impact score

Drug responses associated with RAB36 mutations

All proteins holding degron of PPTTS