DegronMD - Q96Q42(ALS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T504M	TCGA-A6-6781	COAD	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	TCGA-EO-A3AV	UCEC	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	DO8447	COAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	DO52412	UCEC	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	SIDM00251	Gastric Carcinoma	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	ACH-000318	Esophageal Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	ACH-000949	Gastric Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.T504M	TGBC11TKB	stomach	COSMIC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.25
p.R480Q	TCGA-AA-3984	COAD	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.6218
p.R480Q	DO9002	COAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.6218
p.R501W	TCGA-AJ-A3OK	UCEC	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1667
p.R501W	DO46988	RECA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1667
p.R501W	DO43602	UCEC	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1667
p.G478D	TCGA-BS-A0UF	UCEC	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.2778
p.G478D	DO41488	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.2778
p.S492F	TCGA-D3-A8GI	SKCM	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation blocking phosphorylation signal	0.6667
p.S492F	TCGA-EE-A20C	SKCM	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation blocking phosphorylation signal	0.6667
p.S492F	DO222775	MELA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation blocking phosphorylation signal	0.6667
p.S492F	DO50284	SKCM	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation blocking phosphorylation signal	0.6667
p.S492F	DO47665	SKCM	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation blocking phosphorylation signal	0.6667
p.A499D	TCGA-D5-6536	COAD	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1111
p.A499D	DO8200	COAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1111
p.P511H	TCGA-DA-A1IB	SKCM	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.7694
p.P511H	DO38033	SKCM	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.7694
p.P493L	TCGA-EE-A2MC	SKCM	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.1944
p.P493L	DO222426	MELA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.1944
p.P493L	DO37559	SKCM	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.1944
p.P379L	TCGA-EE-A2MD	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.P379L	DO222434	MELA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.P379L	DO37851	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.E472G	TCGA-FI-A2D5	UCEC	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.1111
p.E472G	DO41331	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.1111
p.L484I	TCGA-IB-7651	PAAD	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7174
p.L484I	DO46657	PAAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7174
p.T510S	TCGA-PK-A5HB	ACC	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.8227
p.R497G	TCGA-QR-A70N	PCPG	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.0833
p.R497G	TCGA-QR-A70N	PCPG	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.0556
p.P379S	TCGA-RP-A695	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.P379S	DO51270	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.I470T	TCGA-WQ-A9G7	LIHC	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.0556
p.I470T	DO52326	LIHC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.0556
p.G477E	TCGA-XF-A9SJ	BLCA	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.25
p.G477E	DO219045	BLCA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.25
p.E511K	DO218173	BRCA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.7022
p.E511K	DO233665	GACA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.7022
p.Q375E	DO2819	BRCA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.0833
p.E511D	DO222608	BTCA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.6758
p.E485K	DO49095	COAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7022
p.E485K	DO229346	LAML	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7022
p.H515N	DO9002	COAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.3056
p.G486R	DO230347	COCA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.6457
p.I378M	DO222798	COCA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1667
p.S385Y	DO222798	COCA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.712
p.E476K	DO223052	ESCA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.2222
p.R501Q	DO233109	GACA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1667
p.G381R	DO233759	GACA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.D493G	DO49052	HNSC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.1944
p.E393K	DO14188	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.F388L	DO228976	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.6981
p.P522H	DO229019	LICA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1111
p.T510N	DO229015	LICA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.8166
p.Q490K	DO229045	LICA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.2778
p.A519E	DO229008	LICA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1944
p.V381M	DO50951	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.N499D	DO49870	LUAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1111
p.E384D	DO25847	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.6758
p.V508F	DO224563	LUSC	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.5957
p.G386V	DO26512	LUSC	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7532
p.Y487H	DO38404	STAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7229
p.G395E	DO48009	STAD	ICGC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1389
p.E485G	DO42033	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7199
p.E485G	DO42201	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7199
p.L392Q	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.L392Q	ACH-000562	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.L392Q	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.2222
p.K498M	SIDM00590	Oral Cavity Carcinoma	GDSC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation substituting flanking lysine	0.1667
p.K498M	SIDM00590	Oral Cavity Carcinoma	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation substituting flanking lysine	0.1944
p.K498M	ACH-000472	Head and Neck Cancer	CCLE	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation substituting flanking lysine	0.1667
p.K498M	ACH-000472	Head and Neck Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation substituting flanking lysine	0.1944
p.K498M	HSC-2	upper aerodigestive tract	COSMIC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation substituting flanking lysine	0.1667
p.K498M	HSC-2	upper aerodigestive tract	COSMIC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation substituting flanking lysine	0.1944
p.S514N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation altering degron motif	0.7069
p.G477R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.25
p.G477R	ACH-000951	Lung Cancer	CCLE	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.25
p.G477R	NCI-H2342	lung	COSMIC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation rewiring degron network	0.25
p.P384L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7582
p.P384L	ACH-001638	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7582
p.P384L	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7582
p.P522L	SIDM01450	Gastric Carcinoma	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1111
p.P522L	ACH-000898	Gastric Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	507:514	Mutation rewiring degron network	0.1111
p.A391V	ACH-001699	Head and Neck Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.25
p.S483F	ACH-002396	Bone Cancer	CCLE	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7982
p.S483F	Sarc9371	bone	COSMIC	RRLSLPGLL	DEG_APCC_DBOX_1	480:488	Mutation altering degron motif	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALS2

UniProt ID: Q96Q42

Entrez ID: 57679

Protein name: Alsin (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein) (Amyotrophic lateral sclerosis 2 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALS2 in