DegronMD

Uniprot ID: Q96Q42

Source protein: Alsin

Source gene: ALS2

Class: DEG_APCC_DBOX_1

Location: 480:488

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9994

ASA_SCORE: 74.3

COIL: 0.7352

CONS_SCORE: 0.3792

DSS_SCORE: 0.4673

HELIX: 0.1134

FCONS_SCORE: 1.0645

RIG_SCORE: 0.712

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R480Q	TCGA-AA-3984	COAD	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.6218
p.R480Q	DO9002	COAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.6218
p.G478D	TCGA-BS-A0UF	UCEC	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.2778
p.G478D	DO41488	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.2778
p.S492F	TCGA-D3-A8GI	SKCM	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.6667
p.S492F	TCGA-EE-A20C	SKCM	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.6667
p.S492F	DO222775	MELA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.6667
p.S492F	DO50284	SKCM	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.6667
p.S492F	DO47665	SKCM	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.6667
p.P493L	TCGA-EE-A2MC	SKCM	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.1944
p.P493L	DO222426	MELA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.1944
p.P493L	DO37559	SKCM	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.1944
p.E472G	TCGA-FI-A2D5	UCEC	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.1111
p.E472G	DO41331	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.1111
p.L484I	TCGA-IB-7651	PAAD	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.7174
p.L484I	DO46657	PAAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7174
p.R497G	TCGA-QR-A70N	PCPG	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.0833
p.I470T	TCGA-WQ-A9G7	LIHC	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.0556
p.I470T	DO52326	LIHC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.0556
p.G477E	TCGA-XF-A9SJ	BLCA	TCGA	RRLSLPGLL	DEG_APCC_DBOX_1	0.25
p.G477E	DO219045	BLCA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.25
p.E485K	DO49095	COAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7022
p.E485K	DO229346	LAML	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7022
p.G486R	DO230347	COCA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.6457
p.E476K	DO223052	ESCA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.2222
p.D493G	DO49052	HNSC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.1944
p.Q490K	DO229045	LICA	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.2778
p.Y487H	DO38404	STAD	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7229
p.E485G	DO42033	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7199
p.E485G	DO42201	UCEC	ICGC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7199
p.K498M	SIDM00590	Oral Cavity Carcinoma	GDSC	RRLSLPGLL	DEG_APCC_DBOX_1	0.1667
p.K498M	ACH-000472	Head and Neck Cancer	CCLE	RRLSLPGLL	DEG_APCC_DBOX_1	0.1667
p.K498M	HSC-2	upper_aerodigestive_tract	COSMIC	RRLSLPGLL	DEG_APCC_DBOX_1	0.1667
p.G477R	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	RRLSLPGLL	DEG_APCC_DBOX_1	0.25
p.G477R	ACH-000951	Lung Cancer	CCLE	RRLSLPGLL	DEG_APCC_DBOX_1	0.25
p.G477R	NCI-H2342	lung	COSMIC	RRLSLPGLL	DEG_APCC_DBOX_1	0.25
p.S483F	ACH-002396	Bone Cancer	CCLE	RRLSLPGLL	DEG_APCC_DBOX_1	0.7982
p.S483F	Sarc9371	bone	COSMIC	RRLSLPGLL	DEG_APCC_DBOX_1	0.7982

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRLSLPGLL

Degron related mutations and impact score

Drug responses associated with ALS2 mutations

All proteins holding degron of RRLSLPGLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q42	Alsin	DEG_APCC_DBOX_1	480:488	RRLSLPGLL	APC,CDC20,FZR1	0.9994	More...