DegronMD

Uniprot ID: Q96Q42

Source protein: Alsin

Source gene: ALS2

Class: DEG_SCF_FBW7_1

Location: 507:514

E3 ligase: FBXW7

DEGRON score: 0.5195

ASA_SCORE: 64.875

COIL: 0.546

CONS_SCORE: 0.3023

DSS_SCORE: 0.2885

HELIX: 0.036

FCONS_SCORE: 0.8721

RIG_SCORE: 0.8341

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T504M	TCGA-A6-6781	COAD	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	TCGA-EO-A3AV	UCEC	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	DO8447	COAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	DO52412	UCEC	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	SIDM00251	Gastric Carcinoma	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	ACH-000318	Esophageal Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	ACH-000949	Gastric Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.T504M	TGBC11TKB	stomach	COSMIC	VVLTPTYS	DEG_SCF_FBW7_1	0.25
p.R501W	TCGA-AJ-A3OK	UCEC	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.1667
p.R501W	DO46988	RECA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1667
p.R501W	DO43602	UCEC	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1667
p.A499D	TCGA-D5-6536	COAD	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.1111
p.A499D	DO8200	COAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1111
p.P511H	TCGA-DA-A1IB	SKCM	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.7694
p.P511H	DO38033	SKCM	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.7694
p.T510S	TCGA-PK-A5HB	ACC	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.8227
p.R497G	TCGA-QR-A70N	PCPG	TCGA	VVLTPTYS	DEG_SCF_FBW7_1	0.0556
p.E511K	DO218173	BRCA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.7022
p.E511K	DO233665	GACA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.7022
p.E511D	DO222608	BTCA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.6758
p.H515N	DO9002	COAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.3056
p.R501Q	DO233109	GACA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1667
p.P522H	DO229019	LICA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1111
p.T510N	DO229015	LICA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.8166
p.A519E	DO229008	LICA	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1944
p.N499D	DO49870	LUAD	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.1111
p.V508F	DO224563	LUSC	ICGC	VVLTPTYS	DEG_SCF_FBW7_1	0.5957
p.K498M	SIDM00590	Oral Cavity Carcinoma	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	0.1944
p.K498M	ACH-000472	Head and Neck Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	0.1944
p.K498M	HSC-2	upper_aerodigestive_tract	COSMIC	VVLTPTYS	DEG_SCF_FBW7_1	0.1944
p.S514N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	0.7069
p.P522L	SIDM01450	Gastric Carcinoma	GDSC	VVLTPTYS	DEG_SCF_FBW7_1	0.1111
p.P522L	ACH-000898	Gastric Cancer	CCLE	VVLTPTYS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVLTPTYS

Degron related mutations and impact score

Drug responses associated with ALS2 mutations

All proteins holding degron of VVLTPTYS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q42	Alsin	DEG_SCF_FBW7_1	507:514	VVLTPTYS	FBXW7	0.5195	More...