DegronMD

Uniprot ID: Q96Q42

Source protein: Alsin

Source gene: ALS2

Class: DEG_SPOP_SBC_1

Location: 384:388

E3 ligase: SPOP

DEGRON score: 0.957

ASA_SCORE: 84.36

COIL: 0.9386

CONS_SCORE: 0.303

DSS_SCORE: 0.4574

HELIX: 0.0364

FCONS_SCORE: 0.9941

RIG_SCORE: 0.6586

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P379L	TCGA-EE-A2MD	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	0.1944
p.P379L	DO222434	MELA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1944
p.P379L	DO37851	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1944
p.P379S	TCGA-RP-A695	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	0.1944
p.P379S	DO51270	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1944
p.Q375E	DO2819	BRCA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.0833
p.I378M	DO222798	COCA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1667
p.S385Y	DO222798	COCA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.712
p.G381R	DO233759	GACA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.25
p.E393K	DO14188	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1944
p.F388L	DO228976	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.6981
p.V381M	DO50951	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	0.25
p.E384D	DO25847	LUAD	ICGC	PPTTS	DEG_SPOP_SBC_1	0.6758
p.G386V	DO26512	LUSC	ICGC	PPTTS	DEG_SPOP_SBC_1	0.7532
p.G395E	DO48009	STAD	ICGC	PPTTS	DEG_SPOP_SBC_1	0.1389
p.L392Q	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.L392Q	ACH-000562	Lung Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.2222
p.L392Q	HCC-78	lung	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.2222
p.P384L	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPTTS	DEG_SPOP_SBC_1	0.7582
p.P384L	ACH-001638	Lymphoma	CCLE	PPTTS	DEG_SPOP_SBC_1	0.7582
p.P384L	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	PPTTS	DEG_SPOP_SBC_1	0.7582
p.A391V	ACH-001699	Head and Neck Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	66:70	PPTTS	SPOP	0.9159	More...
O95248	Myotubularin-related protein 5	DEG_SPOP_SBC_1	353:357	PPTTS	SPOP	0.8488	More...
P01106	Myc proto-oncogene protein	DEG_SPOP_SBC_1	245:249	PPTTS	SPOP	0.9673	More...
P15976	Erythroid transcription factor	DEG_SPOP_SBC_1	400:404	PPTTS	SPOP	0.9764	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1492:1496	PPTTS	SPOP	0.7371	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3135:3139	PPTTS	SPOP	0.6836	More...
Q12857	Nuclear factor 1 A-type	DEG_SPOP_SBC_1	458:462	PPTTS	SPOP	0.9881	More...
Q16549	Proprotein convertase subtilisin/kexin type 7	DEG_SPOP_SBC_1	741:745	PPTTS	SPOP	0.9748	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	921:925	PPTTS	SPOP	0.9871	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	387:391	PPTTS	SPOP	0.9613	More...
Q86VF5	2-acylglycerol O-acyltransferase 3	DEG_SPOP_SBC_1	9:13	PPTTS	SPOP	0.9231	More...
Q8IZC6	Collagen alpha-1	DEG_SPOP_SBC_1	444:448	PPTTS	SPOP	0.9481	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	851:855	PPTTS	SPOP	0.9986	More...
Q96Q42	Alsin	DEG_SPOP_SBC_1	384:388	PPTTS	SPOP	0.957	More...
Q9NQX3	Gephyrin [Includes: Molybdopterin adenylyltransferase	DEG_SPOP_SBC_1	196:200	PPTTS	SPOP	0.9868	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	923:927	PPTTS	SPOP	0.6646	More...
A7MBM2	Protein dispatched homolog 2	DEG_SPOP_SBC_1	73:77	PPTTS	SPOP	0.8424	More...
O95755	Ras-related protein Rab-36	DEG_SPOP_SBC_1	21:25	PPTTS	SPOP	0.8571	More...
Q96LK8	Spermatogenesis-associated protein 32	DEG_SPOP_SBC_1	216:220	PPTTS	SPOP	0.7106	More...
Q8NC54	Keratinocyte-associated transmembrane protein 2	DEG_SPOP_SBC_1	89:93	PPTTS	SPOP	0.9928	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTS

Degron related mutations and impact score

Drug responses associated with ALS2 mutations

All proteins holding degron of PPTTS