DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
PPTTS
Uniprot ID:
Q92954
Source protein:
Proteoglycan 4
Source gene:
PRG4
Class:
DEG_SPOP_SBC_1
Location:
851:855
E3 ligase:
SPOP
DEGRON score:
0.9986
ASA_SCORE:
100.08
COIL:
0.9682
CONS_SCORE:
0.3247
DSS_SCORE:
0.8206
HELIX:
0.0156
FCONS_SCORE:
1.0809
RIG_SCORE:
0.5447
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E856D
TCGA-EY-A215
UCEC
TCGA
PPTTS
DEG_SPOP_SBC_1
0.3056
p.E856D
DO233729
GACA
ICGC
PPTTS
DEG_SPOP_SBC_1
0.3056
p.E856D
DO42665
UCEC
ICGC
PPTTS
DEG_SPOP_SBC_1
0.3056
p.K841R
DO229377
BTCA
ICGC
PPTTS
DEG_SPOP_SBC_1
0.5
p.S855P
ACH-000990
Endometrial/Uterine Cancer
CCLE
PPTTS
DEG_SPOP_SBC_1
0.6752
p.T864S
FU97
stomach
COSMIC
PPTTS
DEG_SPOP_SBC_1
0.1944
p.E865D
D-283MED
central_nervous_system
COSMIC
PPTTS
DEG_SPOP_SBC_1
0.0556
p.K843M
OC-314
ovary
COSMIC
PPTTS
DEG_SPOP_SBC_1
0.1111
Drug responses associated with PRG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15481
Melanoma-associated antigen B4
DEG_SPOP_SBC_1
66:70
PPTTS
SPOP
0.9159
More...
O95248
Myotubularin-related protein 5
DEG_SPOP_SBC_1
353:357
PPTTS
SPOP
0.8488
More...
P01106
Myc proto-oncogene protein
DEG_SPOP_SBC_1
245:249
PPTTS
SPOP
0.9673
More...
P15976
Erythroid transcription factor
DEG_SPOP_SBC_1
400:404
PPTTS
SPOP
0.9764
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
1492:1496
PPTTS
SPOP
0.7371
More...
P98088
Mucin-5AC
DEG_SPOP_SBC_1
3135:3139
PPTTS
SPOP
0.6836
More...
Q12857
Nuclear factor 1 A-type
DEG_SPOP_SBC_1
458:462
PPTTS
SPOP
0.9881
More...
Q16549
Proprotein convertase subtilisin/kexin type 7
DEG_SPOP_SBC_1
741:745
PPTTS
SPOP
0.9748
More...
Q53TQ3
INO80 complex subunit D
DEG_SPOP_SBC_1
921:925
PPTTS
SPOP
0.9871
More...
Q86TC9
Myopalladin
DEG_SPOP_SBC_1
387:391
PPTTS
SPOP
0.9613
More...
Q86VF5
2-acylglycerol O-acyltransferase 3
DEG_SPOP_SBC_1
9:13
PPTTS
SPOP
0.9231
More...
Q8IZC6
Collagen alpha-1
DEG_SPOP_SBC_1
444:448
PPTTS
SPOP
0.9481
More...
Q92954
Proteoglycan 4
DEG_SPOP_SBC_1
851:855
PPTTS
SPOP
0.9986
More...
Q96Q42
Alsin
DEG_SPOP_SBC_1
384:388
PPTTS
SPOP
0.957
More...
Q9NQX3
Gephyrin [Includes: Molybdopterin adenylyltransferase
DEG_SPOP_SBC_1
196:200
PPTTS
SPOP
0.9868
More...
Q9Y566
SH3 and multiple ankyrin repeat domains protein 1
DEG_SPOP_SBC_1
923:927
PPTTS
SPOP
0.6646
More...
A7MBM2
Protein dispatched homolog 2
DEG_SPOP_SBC_1
73:77
PPTTS
SPOP
0.8424
More...
O95755
Ras-related protein Rab-36
DEG_SPOP_SBC_1
21:25
PPTTS
SPOP
0.8571
More...
Q96LK8
Spermatogenesis-associated protein 32
DEG_SPOP_SBC_1
216:220
PPTTS
SPOP
0.7106
More...
Q8NC54
Keratinocyte-associated transmembrane protein 2
DEG_SPOP_SBC_1
89:93
PPTTS
SPOP
0.9928
More...