DegronMD - Q96LK8(SPATA32)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H263Y	TCGA-05-4430	LUAD	TCGA	SRMDLPSLE	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.3056
p.D211N	TCGA-13-1477	OV	TCGA	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1944
p.H213Y	TCGA-3N-A9WC	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.25
p.H213Y	DO51234	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.25
p.E365D	TCGA-AN-A046	BRCA	TCGA	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation altering degron motif	0.6758
p.E365D	DO1285	BRCA	ICGC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation altering degron motif	0.6758
p.P367L	TCGA-AP-A059	UCEC	TCGA	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation altering degron motif	0.6471
p.P367L	DO41361	UCEC	ICGC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation altering degron motif	0.6471
p.F244C	TCGA-B5-A1MR	UCEC	TCGA	SRMDLPSLE	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556
p.F244C	DO41758	UCEC	ICGC	SRMDLPSLE	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0556
p.P226L	TCGA-DA-A1IC	SKCM	TCGA	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.P226L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.P226L	ACH-000983	Leukemia	CCLE	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.L207F	TCGA-EI-6917	READ	TCGA	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.0833
p.S221F	TCGA-EY-A1GS	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.3056
p.S225I	TCGA-FI-A2D5	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1944
p.S225I	DO41331	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1944
p.S357L	TCGA-FR-A726	SKCM	TCGA	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.1667
p.L227P	DO233205	GACA	ICGC	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1389
p.A245T	DO233944	GACA	ICGC	SRMDLPSLE	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.0833
p.P248H	DO228943	LICA	ICGC	SRMDLPSLE	DEG_APCC_DBOX_1	254:262	Mutation rewiring degron network	0.1667
p.S353R	DO229037	LICA	ICGC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.0556
p.E365Q	DO23154	LINC	ICGC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation altering degron motif	0.6744
p.E365Q	DO45085	LINC	ICGC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation altering degron motif	0.6744
p.I360M	DO39823	THCA	ICGC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.25
p.P210T	SIDM00806	Osteosarcoma	GDSC	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.P210T	HOS	bone	COSMIC	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation rewiring degron network	0.1667
p.P359S	SIDM00265	Ewing's Sarcoma	GDSC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.2222
p.P359S	ACH-002104	Bone Cancer	CCLE	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.2222
p.P359S	ES3	bone	COSMIC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.2222
p.S377L	SIDM00963	Breast Carcinoma	GDSC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.0556
p.S377L	ACH-000927	Breast Cancer	CCLE	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.0556
p.S377L	BT-474	breast	COSMIC	EKENP	DEG_APCC_KENBOX_2	363:367	Mutation rewiring degron network	0.0556
p.P216S	ACH-001484	Leukemia	CCLE	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation altering degron motif	0.6752
p.P216S	ACH-001485	Leukemia	CCLE	PPTTS	DEG_SPOP_SBC_1	216:220	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA32

UniProt ID: Q96LK8

Entrez ID: 124783

Protein name: Spermatogenesis-associated protein 32 (Testis-expressed protein 34)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA32 in