DegronMD

Uniprot ID: Q96LK8

Source protein: Spermatogenesis-associated protein 32

Source gene: SPATA32

Class: DEG_APCC_DBOX_1

Location: 254:262

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6257

ASA_SCORE: 87.9

COIL: 0.7606

CONS_SCORE: 0.7768

DSS_SCORE: 0.5039

HELIX: 0.203

FCONS_SCORE: 1.0343

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H263Y	TCGA-05-4430	LUAD	TCGA	SRMDLPSLE	DEG_APCC_DBOX_1	0.3056
p.F244C	TCGA-B5-A1MR	UCEC	TCGA	SRMDLPSLE	DEG_APCC_DBOX_1	0.0556
p.F244C	DO41758	UCEC	ICGC	SRMDLPSLE	DEG_APCC_DBOX_1	0.0556
p.A245T	DO233944	GACA	ICGC	SRMDLPSLE	DEG_APCC_DBOX_1	0.0833
p.P248H	DO228943	LICA	ICGC	SRMDLPSLE	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LK8	Spermatogenesis-associated protein 32	DEG_APCC_DBOX_1	254:262	SRMDLPSLE	APC,CDC20,FZR1	0.6257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons