DegronMD

Uniprot ID: Q96LK8

Source protein: Spermatogenesis-associated protein 32

Source gene: SPATA32

Class: DEG_APCC_KENBOX_2

Location: 363:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8459

ASA_SCORE: 100.46

COIL: 0.9068

CONS_SCORE: 0.7257

DSS_SCORE: 0.556

HELIX: 0.0248

FCONS_SCORE: 0.9266

RIG_SCORE: 0.6844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E365D	TCGA-AN-A046	BRCA	TCGA	EKENP	DEG_APCC_KENBOX_2	0.6758
p.E365D	DO1285	BRCA	ICGC	EKENP	DEG_APCC_KENBOX_2	0.6758
p.P367L	TCGA-AP-A059	UCEC	TCGA	EKENP	DEG_APCC_KENBOX_2	0.6471
p.P367L	DO41361	UCEC	ICGC	EKENP	DEG_APCC_KENBOX_2	0.6471
p.S357L	TCGA-FR-A726	SKCM	TCGA	EKENP	DEG_APCC_KENBOX_2	0.1667
p.S353R	DO229037	LICA	ICGC	EKENP	DEG_APCC_KENBOX_2	0.0556
p.E365Q	DO23154	LINC	ICGC	EKENP	DEG_APCC_KENBOX_2	0.6744
p.E365Q	DO45085	LINC	ICGC	EKENP	DEG_APCC_KENBOX_2	0.6744
p.I360M	DO39823	THCA	ICGC	EKENP	DEG_APCC_KENBOX_2	0.25
p.P359S	SIDM00265	Ewing's Sarcoma	GDSC	EKENP	DEG_APCC_KENBOX_2	0.2222
p.P359S	ACH-002104	Bone Cancer	CCLE	EKENP	DEG_APCC_KENBOX_2	0.2222
p.P359S	ES3	bone	COSMIC	EKENP	DEG_APCC_KENBOX_2	0.2222
p.S377L	SIDM00963	Breast Carcinoma	GDSC	EKENP	DEG_APCC_KENBOX_2	0.0556
p.S377L	ACH-000927	Breast Cancer	CCLE	EKENP	DEG_APCC_KENBOX_2	0.0556
p.S377L	BT-474	breast	COSMIC	EKENP	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_APCC_KENBOX_2	1412:1416	EKENP	APC,CDC20,FZR1	0.9937	More...
Q96LK8	Spermatogenesis-associated protein 32	DEG_APCC_KENBOX_2	363:367	EKENP	APC,CDC20,FZR1	0.8459	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons