DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: DEG_APCC_KENBOX_2

Location: 1412:1416

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9937

ASA_SCORE: 118.54

COIL: 0.808

CONS_SCORE: 0.3242

DSS_SCORE: 0.6828

HELIX: 0.1846

FCONS_SCORE: 0.9877

RIG_SCORE: 0.659

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1419M	TCGA-EE-A20F	SKCM	TCGA	EKENP	DEG_APCC_KENBOX_2	0.25
p.R1419M	DO37961	SKCM	ICGC	EKENP	DEG_APCC_KENBOX_2	0.25
p.P1416R	DO50782	LICA	ICGC	EKENP	DEG_APCC_KENBOX_2	0.6401
p.K1418N	DO229453	SKCA	ICGC	EKENP	DEG_APCC_KENBOX_2	0.2778
p.R1426C	HT-115	large_intestine	COSMIC	EKENP	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_APCC_KENBOX_2	1412:1416	EKENP	APC,CDC20,FZR1	0.9937	More...
Q96LK8	Spermatogenesis-associated protein 32	DEG_APCC_KENBOX_2	363:367	EKENP	APC,CDC20,FZR1	0.8459	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons