DegronMD - O95755(RAB36)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L10F	TCGA-2W-A8YY	CESC	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1389
p.L10F	DO223732	CESC	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1389
p.R28C	TCGA-34-5929	LUSC	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.2222
p.R28C	TCGA-34-5929	LUSC	TCGA	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.25
p.R28C	DO26659	LUSC	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.2222
p.R28C	DO26659	LUSC	ICGC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.25
p.D81N	TCGA-AA-A010	COAD	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1667
p.D81N	DO222798	COCA	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1667
p.R80H	TCGA-AJ-A8CV	UCEC	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.R80H	TCGA-AX-A3FT	UCEC	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.R80H	DO219766	UCEC	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.R80H	DO40801	UCEC	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.P76S	TCGA-AP-A1DK	UCEC	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.P76S	DO42033	UCEC	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.S61L	TCGA-BJ-A0ZB	THCA	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1667
p.S61L	DO39363	THCA	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1667
p.R80C	TCGA-BR-7704	STAD	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.R80C	DO38360	STAD	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1944
p.T26M	TCGA-DU-6392	LGG	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation blocking phosphorylation signal	0.7222
p.T26M	TCGA-DU-6392	LGG	TCGA	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation blocking phosphorylation signal	0.75
p.T26M	DO22237	LGG	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation blocking phosphorylation signal	0.7222
p.T26M	DO22237	LGG	ICGC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation blocking phosphorylation signal	0.75
p.P60S	TCGA-FI-A2D4	UCEC	TCGA	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.P60S	DO43170	UCEC	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.1389
p.R12L	TCGA-P3-A6SX	HNSC	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1944
p.R12L	TCGA-P3-A6SX	HNSC	TCGA	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.R12L	DO49051	HNSC	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1944
p.R12L	DO49051	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0833
p.R66T	DO4018	BRCA	ICGC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.3056
p.A14S	DO228985	LICA	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.25
p.A14S	DO228985	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1389
p.V35L	DO229024	LICA	ICGC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0556
p.P22H	SIDM00120	Prostate Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.6583
p.P22H	SIDM00120	Prostate Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.6583
p.P22H	ACH-000979	Prostate Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.6583
p.P22H	ACH-000979	Prostate Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.6583
p.P22H	DU-145	prostate	COSMIC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.6583
p.P22H	DU-145	prostate	COSMIC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.6583
p.G75R	SIDM00477	Esophageal Carcinoma	GDSC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6457
p.G75R	ACH-000383	Esophageal Cancer	CCLE	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6457
p.G75R	OE33	oesophagus	COSMIC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6457
p.V35E	SIDM00308	Chronic Myelogenous Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0556
p.V35E	SIDM00112	Kidney Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0556
p.V35E	SIDM00241	Breast Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0556
p.V35E	SIDM00164	Biliary Tract Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0556
p.V35E	SIDM01694	B-Lymphoblastic Leukemia	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.0556
p.P77L	SIDM00333	Endometrial Carcinoma	GDSC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2778
p.P77L	ACH-000988	Endometrial/Uterine Cancer	CCLE	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2778
p.P77L	MFE-319	endometrium	COSMIC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation rewiring degron network	0.2778
p.T23M	SIDM01088	Endometrial Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.7423
p.T23M	SIDM01088	Endometrial Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.8534
p.T23M	ACH-000965	Endometrial/Uterine Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.7423
p.T23M	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.8534
p.T23M	RL95-2	endometrium	COSMIC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.7423
p.T23M	RL95-2	endometrium	COSMIC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation altering degron motif	0.8534
p.T72S	SIDM00870	Breast Carcinoma	GDSC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6005
p.T72S	ACH-000725	Breast Cancer	CCLE	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6005
p.T72S	HCC202	breast	COSMIC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6005
p.S7C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.0556
p.S7C	ACH-000912	Lung Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.0556
p.S16R	SIDM01451	Pancreatic Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.3056
p.S16R	SIDM01451	Pancreatic Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.S16R	ACH-000933	Pancreatic Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.3056
p.S16R	ACH-000933	Pancreatic Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	21:25	Mutation rewiring degron network	0.1944
p.S70P	ACH-000436	Myeloma	CCLE	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6752
p.S69P	ACH-000948	Gastric Cancer	CCLE	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6752
p.S69P	23132-87	stomach	COSMIC	MRSSLTPLG	DEG_APCC_DBOX_1	67:75	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB36

UniProt ID: O95755

Entrez ID: 9609

Protein name: Ras-related protein Rab-36

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB36 in