DegronMD

Uniprot ID: O95755

Source protein: Ras-related protein Rab-36

Source gene: RAB36

Class: DEG_SCF_FBW7_1

Location: 17:24

E3 ligase: FBXW7

DEGRON score: 0.9627

ASA_SCORE: 82.4125

COIL: 0.9459

CONS_SCORE: 0.1731

DSS_SCORE: 0.5545

HELIX: 0.0271

FCONS_SCORE: 1

RIG_SCORE: 0.689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L10F	TCGA-2W-A8YY	CESC	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	0.1389
p.L10F	DO223732	CESC	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	0.1389
p.R28C	TCGA-34-5929	LUSC	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	0.2222
p.R28C	DO26659	LUSC	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	0.2222
p.T26M	TCGA-DU-6392	LGG	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	0.7222
p.T26M	DO22237	LGG	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	0.7222
p.R12L	TCGA-P3-A6SX	HNSC	TCGA	PTQTPPTT	DEG_SCF_FBW7_1	0.1944
p.R12L	DO49051	HNSC	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	0.1944
p.A14S	DO228985	LICA	ICGC	PTQTPPTT	DEG_SCF_FBW7_1	0.25
p.P22H	SIDM00120	Prostate Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	0.6583
p.P22H	ACH-000979	Prostate Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	0.6583
p.P22H	DU-145	prostate	COSMIC	PTQTPPTT	DEG_SCF_FBW7_1	0.6583
p.T23M	SIDM01088	Endometrial Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	0.7423
p.T23M	ACH-000965	Endometrial/Uterine Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	0.7423
p.T23M	RL95-2	endometrium	COSMIC	PTQTPPTT	DEG_SCF_FBW7_1	0.7423
p.S7C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	0.0556
p.S7C	ACH-000912	Lung Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	0.0556
p.S16R	SIDM01451	Pancreatic Carcinoma	GDSC	PTQTPPTT	DEG_SCF_FBW7_1	0.3056
p.S16R	ACH-000933	Pancreatic Cancer	CCLE	PTQTPPTT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95755	Ras-related protein Rab-36	DEG_SCF_FBW7_1	17:24	PTQTPPTT	FBXW7	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons