DegronMD - Q12857(NFIA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S467I	TCGA-AP-A0LM	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.A456T	TCGA-BG-A222	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.A456V	TCGA-DK-A6AW	BLCA	TCGA	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.G257S	TCGA-GN-A263	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.0556
p.M262I	DO51904	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1944
p.R277C	DO8192	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1667
p.A261T	DO10647	COAD	ICGC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1667
p.P467L	DO10244	COAD	ICGC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.P467L	DO43755	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.S265F	DO220484	KICH	ICGC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation blocking phosphorylation signal	0.7222
p.P456R	DO233292	NACA	ICGC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.2778
p.R277H	DO36556	READ	ICGC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1667
p.P452R	DO37551	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1667
p.P453Q	DO37491	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.P453Q	DO37443	SKCM	ICGC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1944
p.P259T	DO51762	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1111
p.S265L	SIDM01087	Melanoma	GDSC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation blocking phosphorylation signal	0.7222
p.S265L	RPMI-7951	skin	COSMIC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation blocking phosphorylation signal	0.7222
p.P452L	ACH-000231	Brain Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1667
p.P452L	KALS-1	central nervous system	COSMIC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1667
p.Y261C	TE-11	oesophagus	COSMIC	PSTSS	DEG_SPOP_SBC_1	267:271	Mutation rewiring degron network	0.1667
p.V465I	PANC-08-13	pancreas	COSMIC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.25
p.R470W	RKO	large intestine	COSMIC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.1111
p.R449W	RKO	large intestine	COSMIC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation rewiring degron network	0.0833
p.P461L	KMH-2	thyroid	COSMIC	PPTTS	DEG_SPOP_SBC_1	458:462	Mutation altering degron motif	0.7582

Kaplan plot for NFIA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NFIA

UniProt ID: Q12857

Entrez ID: 4774

Protein name: Nuclear factor 1 A-type (NF1-A) (Nuclear factor 1/A) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/A) (NF-I/A) (NFI-A) (TGGCA-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NFIA in