DegronMD - Q9Y566(SHANK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E397V	TCGA-39-5034	LUSC	TCGA	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.0556
p.E397V	DO26854	LUSC	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.0556
p.V408L	TCGA-56-A62T	LUSC	TCGA	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation altering degron motif	0.5654
p.V408L	DO219144	LUSC	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation altering degron motif	0.5654
p.S1171R	TCGA-73-A9RS	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1944
p.S1171R	DO51193	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1944
p.S1171R	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1944
p.S1171R	ACH-000675	Lung Cancer	CCLE	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1944
p.S1171R	NCI-H1734	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1944
p.R898I	TCGA-77-A5GH	LUSC	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.25
p.R898I	DO45452	LUSC	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.25
p.L945F	TCGA-85-A4JB	LUSC	TCGA	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.L945F	DO45517	LUSC	ICGC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.R1170H	TCGA-95-7039	LUAD	TCGA	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.R1170H	DO23907	LUAD	ICGC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.R1170H	SIDM00121	T-Lymphoblastic Leukemia	GDSC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.R1170H	ACH-001738	Leukemia	CCLE	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.S934N	TCGA-AP-A059	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1389
p.S934N	TCGA-AP-A059	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2222
p.S917L	TCGA-AP-A1DV	UCEC	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.25
p.S917L	TCGA-AP-A1DV	UCEC	TCGA	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1667
p.S917L	DO43186	UCEC	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.25
p.S917L	DO43186	UCEC	ICGC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1667
p.Q405K	TCGA-BH-A0DG	BRCA	TCGA	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.2778
p.Q405K	DO1257	BRCA	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.2778
p.K907T	TCGA-BS-A0UV	UCEC	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation altering degron motif	0.6195
p.P929T	TCGA-CV-7242	HNSC	TCGA	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2778
p.P929T	TCGA-CV-7242	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.0833
p.P929T	DO14974	HNSC	ICGC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2778
p.P929T	DO14974	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.0833
p.R944C	TCGA-D5-6541	COAD	TCGA	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.2778
p.P1163Q	TCGA-D9-A149	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation altering degron motif	0.5924
p.P1163Q	DO37420	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation altering degron motif	0.5924
p.M906I	TCGA-DO-A2HM	THCA	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation altering degron motif	0.6507
p.M906I	DO40616	THCA	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation altering degron motif	0.6507
p.S1172I	TCGA-ED-A8O6	LIHC	TCGA	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1667
p.S1172I	TCGA-ER-A19B	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1667
p.S1172I	DO48555	LIHC	ICGC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1667
p.S1172I	DO47491	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.1667
p.A1973T	TCGA-EE-A3J5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation altering degron motif	0.7139
p.L945I	TCGA-HU-A4GT	STAD	TCGA	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.G892V	TCGA-NJ-A4YI	LUAD	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.0833
p.I1158T	TCGA-VQ-A8P2	STAD	TCGA	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.I1158T	DO51761	STAD	ICGC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.P904S	TCGA-Z2-A8RT	SKCM	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation altering degron motif	0.5641
p.P904S	DO51301	SKCM	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation altering degron motif	0.5641
p.P409A	DO52504	EOPC	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation altering degron motif	0.7503
p.R1432Q	DO50396	ESAD	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.0833
p.P1440L	DO234352	ESAD	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.3056
p.R1972H	DO233769	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation rewiring degron network	0.3056
p.A893E	DO229032	LICA	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.1111
p.P899T	DO229035	LICA	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.2778
p.R419W	DO45299	LIRI	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.1389
p.I399M	DO231155	LUSC	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.1111
p.R1982Q	DO26695	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation rewiring degron network	0.1944
p.P947S	DO222434	MELA	ICGC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.R420Q	DO32835	PACA	ICGC	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.1111
p.E1456V	DO220260	SARC	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.1389
p.R1987C	DO229459	SKCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation rewiring degron network	0.0556
p.P1444S	DO229502	SKCA	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation altering degron motif	0.6752
p.E1456K	DO37802	SKCM	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.1389
p.A1964T	DO47331	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation rewiring degron network	0.0833
p.A1431T	DO229229	THCA	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation substituting flanking lysine	0.1667
p.L1451M	DO229242	THCA	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.2778
p.P899L	SIDM00608	Plasma Cell Myeloma	GDSC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation rewiring degron network	0.2778
p.R1981C	SIDM01174	Cervical Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation rewiring degron network	0.2222
p.R1170L	SIDM00484	Thyroid Gland Carcinoma	GDSC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.R1170L	TT	thyroid	COSMIC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.2222
p.P923S	SIDM00217	Colorectal Carcinoma	GDSC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation altering degron motif	0.6752
p.P923S	SNU-1040	large intestine	COSMIC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation altering degron motif	0.6752
p.S1436T	SIDM01432	Kidney Carcinoma	GDSC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation blocking phosphorylation signal	0.6389
p.A1964V	ACH-000939	Sarcoma	CCLE	ASSSS	DEG_SPOP_SBC_1	1973:1977	Mutation rewiring degron network	0.0833
p.A1440V	ACH-000947	Ovarian Cancer	CCLE	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.3056
p.Y933H	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1667
p.Y933H	ACH-000988	Endometrial/Uterine Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.Y933H	MFE-319	endometrium	COSMIC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1667
p.Y933H	MFE-319	endometrium	COSMIC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1944
p.R403Q	ACH-001852	Bile Duct Cancer	CCLE	VVPFQE	LIG_APCC_ABBA_1	407:412	Mutation rewiring degron network	0.2222
p.R1161L	TT	thyroid	COSMIC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.3056
p.F1437V	HT-1376	urinary tract	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.2222
p.V941E	EW-7	bone	COSMIC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.7693
p.G1454V	NCI-H2110	lung	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.1944
p.P1176Q	RERF-LC-MS	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation rewiring degron network	0.0556
p.P914S	SNU-1040	large intestine	COSMIC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	901:914	Mutation altering degron motif	0.6752
p.D945N	NCI-H727	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.25
p.A938T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.7139
p.A1459V	NU-DUL-1	haematopoietic and lymphoid tissue	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.0556
p.Y941H	MFE-319	endometrium	COSMIC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation altering degron motif	0.7229
p.G1447E	H9	haematopoietic and lymphoid tissue	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation altering degron motif	0.7199
p.F1441S	CW-2	large intestine	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation altering degron motif	0.7982
p.P931S	SNU-1040	large intestine	COSMIC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.2222
p.P931S	SNU-1040	large intestine	COSMIC	VPSSS	DEG_SPOP_SBC_1	938:942	Mutation rewiring degron network	0.1389
p.A1455G	TMK-1	stomach	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	1441:1449	Mutation rewiring degron network	0.1667
p.Y924H	MFE-319	endometrium	COSMIC	PPTTS	DEG_SPOP_SBC_1	923:927	Mutation altering degron motif	0.7229
p.S1162R	NCI-H1734	lung	COSMIC	APSTS	DEG_SPOP_SBC_1	1162:1166	Mutation altering degron motif	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHANK1

UniProt ID: Q9Y566

Entrez ID: 50944

Protein name: SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHANK1 in