DegronMD

Uniprot ID: Q9Y566

Source protein: SH3 and multiple ankyrin repeat domains protein 1

Source gene: SHANK1

Class: DEG_APCC_DBOX_1

Location: 1441:1449

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.991

ASA_SCORE: 112.1222

COIL: 0.7226

CONS_SCORE: 0.2986

DSS_SCORE: 0.6088

HELIX: 0.2638

FCONS_SCORE: 1.0145

RIG_SCORE: 0.671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1432Q	DO50396	ESAD	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.0833
p.P1440L	DO234352	ESAD	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.3056
p.E1456V	DO220260	SARC	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.1389
p.P1444S	DO229502	SKCA	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.6752
p.E1456K	DO37802	SKCM	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.1389
p.A1431T	DO229229	THCA	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.1667
p.L1451M	DO229242	THCA	ICGC	RRSLLHRLP	DEG_APCC_DBOX_1	0.2778
p.S1436T	SIDM01432	Kidney Carcinoma	GDSC	RRSLLHRLP	DEG_APCC_DBOX_1	0.6389
p.A1440V	ACH-000947	Ovarian Cancer	CCLE	RRSLLHRLP	DEG_APCC_DBOX_1	0.3056
p.F1437V	HT-1376	urinary_tract	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	0.2222
p.G1454V	NCI-H2110	lung	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	0.1944
p.A1459V	NU-DUL-1	haematopoietic_and_lymphoid_tissue	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	0.0556
p.G1447E	H9	haematopoietic_and_lymphoid_tissue	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	0.7199
p.F1441S	CW-2	large_intestine	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	0.7982
p.A1455G	TMK-1	stomach	COSMIC	RRSLLHRLP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_APCC_DBOX_1	1441:1449	RRSLLHRLP	APC,CDC20,FZR1	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons