DegronMD

Uniprot ID: Q9Y566

Source protein: SH3 and multiple ankyrin repeat domains protein 1

Source gene: SHANK1

Class: DEG_ODPH_VHL_1

Location: 901:914

E3 ligase: VHL

DEGRON score: 0.983

ASA_SCORE: 87.7643

COIL: 0.9115

CONS_SCORE: 0.3165

DSS_SCORE: 0.5715

HELIX: 0.0549

FCONS_SCORE: 0.9664

RIG_SCORE: 0.655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R898I	TCGA-77-A5GH	LUSC	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.25
p.R898I	DO45452	LUSC	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.25
p.S917L	TCGA-AP-A1DV	UCEC	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.25
p.S917L	DO43186	UCEC	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.25
p.K907T	TCGA-BS-A0UV	UCEC	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.6195
p.M906I	TCGA-DO-A2HM	THCA	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.6507
p.M906I	DO40616	THCA	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.6507
p.G892V	TCGA-NJ-A4YI	LUAD	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.0833
p.P904S	TCGA-Z2-A8RT	SKCM	TCGA	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.5641
p.P904S	DO51301	SKCM	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.5641
p.A893E	DO229032	LICA	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.1111
p.P899T	DO229035	LICA	ICGC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.2778
p.P899L	SIDM00608	Plasma Cell Myeloma	GDSC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.2778
p.P914S	SNU-1040	large_intestine	COSMIC	LAPPAMKFSRSLSV	DEG_ODPH_VHL_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_ODPH_VHL_1	901:914	LAPPAMKFSRSLSV	VHL	0.983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons