DegronMD

Uniprot ID: Q9Y566

Source protein: SH3 and multiple ankyrin repeat domains protein 1

Source gene: SHANK1

Class: LIG_APCC_ABBA_1

Location: 407:412

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9223

ASA_SCORE: 81.6

COIL: 0.6638

CONS_SCORE: 0.6182

DSS_SCORE: 0.5166

HELIX: 0.0958

FCONS_SCORE: 1.1283

RIG_SCORE: 0.7607

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E397V	TCGA-39-5034	LUSC	TCGA	VVPFQE	LIG_APCC_ABBA_1	0.0556
p.E397V	DO26854	LUSC	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.0556
p.V408L	TCGA-56-A62T	LUSC	TCGA	VVPFQE	LIG_APCC_ABBA_1	0.5654
p.V408L	DO219144	LUSC	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.5654
p.Q405K	TCGA-BH-A0DG	BRCA	TCGA	VVPFQE	LIG_APCC_ABBA_1	0.2778
p.Q405K	DO1257	BRCA	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.2778
p.P409A	DO52504	EOPC	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.7503
p.R419W	DO45299	LIRI	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.1389
p.I399M	DO231155	LUSC	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.1111
p.R420Q	DO32835	PACA	ICGC	VVPFQE	LIG_APCC_ABBA_1	0.1111
p.R403Q	ACH-001852	Bile Duct Cancer	CCLE	VVPFQE	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	LIG_APCC_ABBA_1	407:412	VVPFQE	APC,CDC20,FZR1	0.9223	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons