DegronMD - Q9C091(GREB1L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1214L	TCGA-2W-A8YY	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	DO223732	CESC	ICGC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	DO234280	ESAD	ICGC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	SIDM00600	Thyroid Gland Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	SIDM00216	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	ACH-000989	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	ACH-001528	Thyroid Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	IHH-4	thyroid	COSMIC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214L	SNU-175	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.R1339C	TCGA-A6-6651	COAD	TCGA	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1339C	TCGA-AA-3956	COAD	TCGA	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1339C	DO9700	COAD	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1339C	DO8328	COAD	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.N1356T	TCGA-AA-3492	COAD	TCGA	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2222
p.N1356T	DO8224	COAD	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2222
p.S284R	TCGA-AA-3815	COAD	TCGA	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1111
p.S284R	DO9924	COAD	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1111
p.D1261G	TCGA-AA-A00N	COAD	TCGA	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.7198
p.D1261G	DO9876	COAD	ICGC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.7198
p.T1210A	TCGA-AP-A1E0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.1944
p.T1210A	DO43154	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.1944
p.V1349M	TCGA-AX-A1CE	UCEC	TCGA	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation altering degron motif	0.6097
p.V1349M	DO42280	UCEC	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation altering degron motif	0.6097
p.R1339H	TCGA-C5-A2LY	CESC	TCGA	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1339H	DO6314	CESC	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1339H	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1339H	LK-2	lung	COSMIC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1111
p.R1269W	TCGA-CI-6622	READ	TCGA	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.1111
p.R1269W	DO36435	READ	ICGC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.1111
p.G1215E	TCGA-DD-A4NQ	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0556
p.G1215E	DO44887	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0556
p.P1214S	TCGA-FI-A2D5	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1214S	DO41331	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation rewiring degron network	0.0833
p.P1251S	TCGA-QG-A5Z2	COAD	TCGA	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.1944
p.P1251S	DO44096	COAD	ICGC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.1944
p.E1361K	DO522	BLCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.0833
p.R1343K	DO224717	BRCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2222
p.Q107H	DO3482	BRCA	ICGC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation altering degron motif	0.647
p.S293F	DO222530	BTCA	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.6871
p.S1195N	DO230311	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation altering degron motif	0.5958
p.T1197S	DO222874	COCA	ICGC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation altering degron motif	0.6005
p.L1152R	DO233267	GACA	ICGC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.S1202P	DO233935	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	1201:1205	Mutation altering degron motif	0.6752
p.A1260S	DO228952	LICA	ICGC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.6477
p.V1265L	DO228952	LICA	ICGC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2222
p.G1190C	DO229031	LICA	ICGC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation rewiring degron network	0.2222
p.E112V	DO231848	LINC	ICGC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.25
p.G301R	DO222632	MELA	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1944
p.E1135D	DO217836	ORCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.25
p.G288E	DO28521	OV	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.2222
p.H299L	DO51527	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.25
p.S304F	DO51527	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1111
p.P297A	DO51527	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.3056
p.L1345P	DO51529	PACA	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2778
p.V1347L	DO232257	PBCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation altering degron motif	0.5654
p.G1248D	DO36556	READ	ICGC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.1111
p.R1343G	DO229213	THCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2222
p.N1356K	DO229227	THCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2222
p.V1262M	SIDM01293	Colorectal Carcinoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.3056
p.A1263G	SIDM01095	Rhabdomyosarcoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2778
p.A1263G	SIDM00027	Kidney Carcinoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2778
p.A1263G	SIDM00736	Non-Cancerous	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2778
p.D92N	SIDM01175	Other Sarcomas	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1389
p.D92N	ACH-002309	Sarcoma	CCLE	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1389
p.D92N	SW684	soft tissue	COSMIC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1389
p.D1261N	SIDM00007	Other Solid Cancers	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.6932
p.D1261N	MCC13	skin	COSMIC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.6932
p.E1185Q	SIDM00924	Other Solid Cancers	GDSC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation rewiring degron network	0.0833
p.E1185Q	ACH-000867	Lung Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation rewiring degron network	0.0833
p.E1185Q	ChaGo-K-1	lung	COSMIC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation rewiring degron network	0.0833
p.S1196I	SIDM00255	Neuroblastoma	GDSC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation altering degron motif	0.7341
p.S1196I	ACH-002282	Neuroblastoma	CCLE	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation altering degron motif	0.7341
p.S1196I	NB17	autonomic ganglia	COSMIC	ASSTT	DEG_SPOP_SBC_1	1194:1198	Mutation altering degron motif	0.7341
p.E93K	SIDM00885	Breast Carcinoma	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.E93K	SIDM00869	Non-Cancerous	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.E93K	SIDM00014	Colorectal Carcinoma	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.E93K	SIDM00256	Neuroblastoma	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.E93K	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.P1258L	SIDM00284	Melanoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.6471
p.P1258L	ACH-000805	Skin Cancer	CCLE	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation altering degron motif	0.6471
p.S1151Y	SIDM00694	Other Solid Cancers	GDSC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0833
p.S1151Y	HUTU-80	small intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0833
p.E93Q	SIDM00779	Colorectal Carcinoma	GDSC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.E93Q	ACH-000491	Colon/Colorectal Cancer	CCLE	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.E93Q	NCI-H716	large intestine	COSMIC	NSPPIPYSQKP	CBL_PTK	99:109	Mutation rewiring degron network	0.1667
p.S1255F	SIDM00380	Acute Myeloid Leukemia	GDSC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.3056
p.S1255F	ACH-000373	Leukemia	CCLE	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.3056
p.S1255F	SKM-1	haematopoietic and lymphoid tissue	COSMIC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.3056
p.S1130L	SIDM00118	Colorectal Carcinoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1111
p.S1130L	ACH-001081	Colon/Colorectal Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1111
p.S1130L	HCC2998	large intestine	COSMIC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.1111
p.V1265M	ACH-000698	Lung Cancer	CCLE	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2222
p.L1345Q	ACH-000842	Colon/Colorectal Cancer	CCLE	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.2778
p.P104S	ACH-001119	Lymphoma	CCLE	NSPPIPYSQKP	CBL_PTK	99:109	Mutation altering degron motif	0.5641
p.S1254C	ACH-001422	Prostate Cancer	CCLE	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2778
p.T300A	ACH-002061	Leukemia	CCLE	ASSST	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.2222
p.S1146F	SKM-1	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation substituting flanking lysine	0.3333
p.S1254R	HT	haematopoietic and lymphoid tissue	COSMIC	LLPHAD	LIG_APCC_ABBA_1	1256:1261	Mutation rewiring degron network	0.2778
p.D1152N	MCC13	skin	COSMIC	VSSSS	DEG_SPOP_SBC_1	1138:1142	Mutation rewiring degron network	0.0556
p.M1340I	SISO	cervix	COSMIC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1389
p.D1341N	Mewo	skin	COSMIC	VDVYDE	LIG_APCC_ABBA_1	1347:1352	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GREB1L

UniProt ID: Q9C091

Entrez ID: 80000

Protein name: GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GREB1L in