DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NSPPIPYSQKP
Uniprot ID:
Q9C091
Source protein:
GREB1-like protein
Source gene:
GREB1L
Class:
CBL_PTK
Location:
99:109
E3 ligase:
CBL
DEGRON score:
0.8896
ASA_SCORE:
90.0818
COIL:
0.9593
CONS_SCORE:
0.5143
DSS_SCORE:
0.7661
HELIX:
0.0196
FCONS_SCORE:
0.9954
RIG_SCORE:
0.588
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q107H
DO3482
BRCA
ICGC
NSPPIPYSQKP
CBL_PTK
0.647
p.E112V
DO231848
LINC
ICGC
NSPPIPYSQKP
CBL_PTK
0.25
p.D92N
SIDM01175
Other Sarcomas
GDSC
NSPPIPYSQKP
CBL_PTK
0.1389
p.D92N
ACH-002309
Sarcoma
CCLE
NSPPIPYSQKP
CBL_PTK
0.1389
p.D92N
SW684
soft_tissue
COSMIC
NSPPIPYSQKP
CBL_PTK
0.1389
p.E93K
SIDM00885
Breast Carcinoma
GDSC
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93K
SIDM00869
Non-Cancerous
GDSC
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93K
SIDM00014
Colorectal Carcinoma
GDSC
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93K
SIDM00256
Neuroblastoma
GDSC
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93K
SIDM00859
B-Cell Non-Hodgkin's Lymphoma
GDSC
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93Q
SIDM00779
Colorectal Carcinoma
GDSC
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93Q
ACH-000491
Colon/Colorectal Cancer
CCLE
NSPPIPYSQKP
CBL_PTK
0.1667
p.E93Q
NCI-H716
large_intestine
COSMIC
NSPPIPYSQKP
CBL_PTK
0.1667
p.P104S
ACH-001119
Lymphoma
CCLE
NSPPIPYSQKP
CBL_PTK
0.5641
Drug responses associated with GREB1L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSPPIPYSQKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C091
GREB1-like protein
CBL_PTK
99:109
NSPPIPYSQKP
CBL
0.8896
More...
