DegronMD

Uniprot ID: Q9C091

Source protein: GREB1-like protein

Source gene: GREB1L

Class: LIG_APCC_ABBA_1

Location: 1256:1261

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.662

ASA_SCORE: 59.9167

COIL: 0.759

CONS_SCORE: 0.7214

DSS_SCORE: 0.2093

HELIX: 0.1755

FCONS_SCORE: 1.3281

RIG_SCORE: 0.7171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1261G	TCGA-AA-A00N	COAD	TCGA	LLPHAD	LIG_APCC_ABBA_1	0.7198
p.D1261G	DO9876	COAD	ICGC	LLPHAD	LIG_APCC_ABBA_1	0.7198
p.R1269W	TCGA-CI-6622	READ	TCGA	LLPHAD	LIG_APCC_ABBA_1	0.1111
p.R1269W	DO36435	READ	ICGC	LLPHAD	LIG_APCC_ABBA_1	0.1111
p.P1251S	TCGA-QG-A5Z2	COAD	TCGA	LLPHAD	LIG_APCC_ABBA_1	0.1944
p.P1251S	DO44096	COAD	ICGC	LLPHAD	LIG_APCC_ABBA_1	0.1944
p.A1260S	DO228952	LICA	ICGC	LLPHAD	LIG_APCC_ABBA_1	0.6477
p.V1265L	DO228952	LICA	ICGC	LLPHAD	LIG_APCC_ABBA_1	0.2222
p.G1248D	DO36556	READ	ICGC	LLPHAD	LIG_APCC_ABBA_1	0.1111
p.V1262M	SIDM01293	Colorectal Carcinoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.3056
p.A1263G	SIDM01095	Rhabdomyosarcoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.2778
p.A1263G	SIDM00027	Kidney Carcinoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.2778
p.A1263G	SIDM00736	Non-Cancerous	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.2778
p.D1261N	SIDM00007	Other Solid Cancers	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.6932
p.D1261N	MCC13	skin	COSMIC	LLPHAD	LIG_APCC_ABBA_1	0.6932
p.P1258L	SIDM00284	Melanoma	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.6471
p.P1258L	ACH-000805	Skin Cancer	CCLE	LLPHAD	LIG_APCC_ABBA_1	0.6471
p.S1255F	SIDM00380	Acute Myeloid Leukemia	GDSC	LLPHAD	LIG_APCC_ABBA_1	0.3056
p.S1255F	ACH-000373	Leukemia	CCLE	LLPHAD	LIG_APCC_ABBA_1	0.3056
p.S1255F	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHAD	LIG_APCC_ABBA_1	0.3056
p.V1265M	ACH-000698	Lung Cancer	CCLE	LLPHAD	LIG_APCC_ABBA_1	0.2222
p.S1254C	ACH-001422	Prostate Cancer	CCLE	LLPHAD	LIG_APCC_ABBA_1	0.2778
p.S1254R	HT	haematopoietic_and_lymphoid_tissue	COSMIC	LLPHAD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C091	GREB1-like protein	LIG_APCC_ABBA_1	1256:1261	LLPHAD	APC,CDC20,FZR1	0.662	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons