DegronMD

Uniprot ID: Q9C091

Source protein: GREB1-like protein

Source gene: GREB1L

Class: LIG_APCC_ABBA_1

Location: 1347:1352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9124

ASA_SCORE: 80.9833

COIL: 0.7488

CONS_SCORE: 0.8009

DSS_SCORE: 0.1779

HELIX: 0.184

FCONS_SCORE: 1.2133

RIG_SCORE: 0.8843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1339C	TCGA-A6-6651	COAD	TCGA	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.R1339C	TCGA-AA-3956	COAD	TCGA	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.R1339C	DO9700	COAD	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.R1339C	DO8328	COAD	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.N1356T	TCGA-AA-3492	COAD	TCGA	VDVYDE	LIG_APCC_ABBA_1	0.2222
p.N1356T	DO8224	COAD	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.2222
p.V1349M	TCGA-AX-A1CE	UCEC	TCGA	VDVYDE	LIG_APCC_ABBA_1	0.6097
p.V1349M	DO42280	UCEC	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.6097
p.R1339H	TCGA-C5-A2LY	CESC	TCGA	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.R1339H	DO6314	CESC	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.R1339H	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.R1339H	LK-2	lung	COSMIC	VDVYDE	LIG_APCC_ABBA_1	0.1111
p.E1361K	DO522	BLCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.0833
p.R1343K	DO224717	BRCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.2222
p.L1345P	DO51529	PACA	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.2778
p.V1347L	DO232257	PBCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.5654
p.R1343G	DO229213	THCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.2222
p.N1356K	DO229227	THCA	ICGC	VDVYDE	LIG_APCC_ABBA_1	0.2222
p.L1345Q	ACH-000842	Colon/Colorectal Cancer	CCLE	VDVYDE	LIG_APCC_ABBA_1	0.2778
p.M1340I	SISO	cervix	COSMIC	VDVYDE	LIG_APCC_ABBA_1	0.1389
p.D1341N	Mewo	skin	COSMIC	VDVYDE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C091	GREB1-like protein	LIG_APCC_ABBA_1	1347:1352	VDVYDE	APC,CDC20,FZR1	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons