DegronMD - Q9H0H5(RACGAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P577S	TCGA-AJ-A3EK	UCEC	TCGA	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1111
p.P577S	DO41584	UCEC	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1111
p.P581S	TCGA-DK-A1AD	BLCA	TCGA	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2222
p.P581S	TCGA-DK-A1AD	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation rewiring degron network	0.1111
p.P581S	DO459	BLCA	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.2222
p.P581S	DO459	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation rewiring degron network	0.1111
p.R597K	TCGA-EO-A3B0	UCEC	TCGA	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1944
p.R597K	TCGA-EO-A3B0	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation rewiring degron network	0.2222
p.R597K	DO219773	UCEC	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1944
p.R597K	DO219773	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation rewiring degron network	0.2222
p.R597T	DO46330	OV	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1944
p.R597T	DO46330	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation rewiring degron network	0.2222
p.P589T	SIDM01240	Melanoma	GDSC	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation altering degron motif	0.7031
p.P589T	SIDM01240	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation altering degron motif	0.7031
p.P589T	ACH-001002	Skin Cancer	CCLE	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation altering degron motif	0.7031
p.P589T	ACH-001002	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation altering degron motif	0.7031
p.P589T	451Lu	skin	COSMIC	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation altering degron motif	0.7031
p.P589T	451Lu	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation altering degron motif	0.7031
p.R599H	ACH-000398	Lymphoma	CCLE	LLKTPSSS	DEG_SCF_FBW7_1	585:592	Mutation rewiring degron network	0.1389
p.R599H	ACH-000398	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	589:593	Mutation rewiring degron network	0.1667

Kaplan plot for RACGAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RACGAP1

UniProt ID: Q9H0H5

Entrez ID: 29127

Protein name: Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RACGAP1 in