DegronMD

Uniprot ID: Q9H0H5

Source protein: Rac GTPase-activating protein 1

Source gene: RACGAP1

Class: DEG_SCF_FBW7_1

Location: 585:592

E3 ligase: FBXW7

DEGRON score: 0.9765

ASA_SCORE: 87

COIL: 0.8618

CONS_SCORE: 0.3967

DSS_SCORE: 0.6184

HELIX: 0.1039

FCONS_SCORE: 0.8869

RIG_SCORE: 0.6763

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P577S	TCGA-AJ-A3EK	UCEC	TCGA	LLKTPSSS	DEG_SCF_FBW7_1	0.1111
p.P577S	DO41584	UCEC	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	0.1111
p.P581S	TCGA-DK-A1AD	BLCA	TCGA	LLKTPSSS	DEG_SCF_FBW7_1	0.2222
p.P581S	DO459	BLCA	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	0.2222
p.R597K	TCGA-EO-A3B0	UCEC	TCGA	LLKTPSSS	DEG_SCF_FBW7_1	0.1944
p.R597K	DO219773	UCEC	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	0.1944
p.R597T	DO46330	OV	ICGC	LLKTPSSS	DEG_SCF_FBW7_1	0.1944
p.P589T	SIDM01240	Melanoma	GDSC	LLKTPSSS	DEG_SCF_FBW7_1	0.7031
p.P589T	ACH-001002	Skin Cancer	CCLE	LLKTPSSS	DEG_SCF_FBW7_1	0.7031
p.P589T	451Lu	skin	COSMIC	LLKTPSSS	DEG_SCF_FBW7_1	0.7031
p.R599H	ACH-000398	Lymphoma	CCLE	LLKTPSSS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0H5	Rac GTPase-activating protein 1	DEG_SCF_FBW7_1	585:592	LLKTPSSS	FBXW7	0.9765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons