DegronMD - Q96F45(ZNF503)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A566T	TCGA-CV-7424	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.A566T	DO14998	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.L552M	TCGA-DU-6392	LGG	TCGA	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2222
p.L552M	DO22237	LGG	ICGC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.2222
p.G547E	TCGA-WB-A80V	PCPG	TCGA	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.0833
p.S318G	DO233791	GACA	ICGC	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.1389
p.V205A	DO233935	GACA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation rewiring degron network	0.3056
p.T223K	DO229008	LICA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation blocking phosphorylation signal	0.6111
p.S558L	DO220902	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7667
p.G203E	DO229227	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation rewiring degron network	0.25
p.F212S	DO229229	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation altering degron motif	0.6871
p.G203W	DO229248	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation rewiring degron network	0.25
p.G200D	DO229240	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation rewiring degron network	0.1667
p.S560P	DO229085	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.6752
p.S321F	SIDM01233	Colorectal Carcinoma	GDSC	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.S321F	ACH-000003		CCLE	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.S321F	ACH-000009	Colon/Colorectal Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.2222
p.S553L	SIDM00596	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.S553L	SIDM00158	Glioblastoma	GDSC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.S553L	ACH-000623	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.S553L	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.S553L	HEC-1	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.25
p.T223R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation blocking phosphorylation signal	0.6111
p.P339S	SIDM00655	Other Solid Cancers	GDSC	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.P339S	ACH-001578	Embryonal Cancer	CCLE	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.P339S	NCCIT	testis	COSMIC	APTSS	DEG_SPOP_SBC_1	325:329	Mutation rewiring degron network	0.0556
p.A567T	SIDM00011	Melanoma	GDSC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1389
p.A567T	ACH-000477	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1389
p.S559L	SIDM01473	Plasma Cell Myeloma	GDSC	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7667
p.S559L	ACH-000541	Myeloma	CCLE	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation altering degron motif	0.7667
p.S206L	ACH-000400	Colon/Colorectal Cancer	CCLE	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation altering degron motif	0.8778
p.A566V	ACH-000969	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	556:560	Mutation rewiring degron network	0.1667
p.P224S	ACH-001403	Ovarian Cancer	CCLE	SSEKSGFRVPSA	DEG_COP1_1	206:217	Mutation rewiring degron network	0.1389

Kaplan plot for ZNF503 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF503

UniProt ID: Q96F45

Entrez ID: 84858

Protein name: Zinc finger protein 503

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF503 in