DegronMD

Uniprot ID: Q96F45

Source protein: Zinc finger protein 503

Source gene: ZNF503

Class: DEG_COP1_1

Location: 206:217

E3 ligase: COP1

DEGRON score: 0.9874

ASA_SCORE: 91.0417

COIL: 0.911

CONS_SCORE: 0.4837

DSS_SCORE: 0.6055

HELIX: 0.0652

FCONS_SCORE: 1.2294

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V205A	DO233935	GACA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	0.3056
p.T223K	DO229008	LICA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	0.6111
p.G203E	DO229227	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	0.25
p.F212S	DO229229	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	0.6871
p.G203W	DO229248	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	0.25
p.G200D	DO229240	THCA	ICGC	SSEKSGFRVPSA	DEG_COP1_1	0.1667
p.T223R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SSEKSGFRVPSA	DEG_COP1_1	0.6111
p.S206L	ACH-000400	Colon/Colorectal Cancer	CCLE	SSEKSGFRVPSA	DEG_COP1_1	0.8778
p.P224S	ACH-001403	Ovarian Cancer	CCLE	SSEKSGFRVPSA	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96F45	Zinc finger protein 503	DEG_COP1_1	206:217	SSEKSGFRVPSA	COP1	0.9874	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons