DegronMD - Q17R98(ZNF827)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T201S	TCGA-34-2604	LUSC	TCGA	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6005
p.T201S	DO26433	LUSC	ICGC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6005
p.P198S	TCGA-A5-A0G2	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6752
p.P198S	DO41235	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation altering degron motif	0.6752
p.R188C	TCGA-B5-A3FA	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.R188C	DO52402	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.K259N	TCGA-CN-A63U	HNSC	TCGA	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation substituting flanking lysine	0.2778
p.K259N	DO44454	HNSC	ICGC	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation substituting flanking lysine	0.2778
p.S205N	TCGA-D1-A103	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.S205N	DO42312	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.25
p.F189I	TCGA-D3-A3C7	SKCM	TCGA	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0833
p.F189I	DO47569	SKCM	ICGC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0833
p.E962K	TCGA-EI-6917	READ	TCGA	PSSSS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.2222
p.D921E	DO229018	LICA	ICGC	MSLHVD	LIG_APCC_ABBA_1	916:921	Mutation altering degron motif	0.5647
p.R188S	DO229019	LICA	ICGC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.S280F	DO229177	LMS	ICGC	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.0556
p.E907K	DO220875	MELA	ICGC	MSLHVD	LIG_APCC_ABBA_1	916:921	Mutation rewiring degron network	0.0833
p.A275T	DO228839	PBCA	ICGC	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation rewiring degron network	0.1944
p.V910D	DO229446	SKCA	ICGC	MSLHVD	LIG_APCC_ABBA_1	916:921	Mutation rewiring degron network	0.1667
p.Q911K	DO229446	SKCA	ICGC	MSLHVD	LIG_APCC_ABBA_1	916:921	Mutation rewiring degron network	0.1944
p.K258R	SIDM00625	Other Sarcomas	GDSC	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation substituting flanking lysine	0.25
p.K258R	ACH-000449	Sarcoma	CCLE	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation substituting flanking lysine	0.25
p.K258R	MES-SA	soft tissue	COSMIC	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation substituting flanking lysine	0.25
p.I190L	SIDM00041	Gastric Carcinoma	GDSC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.I190L	ACH-002306	Gastric Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.I190L	STS-0421	soft tissue	COSMIC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.P208S	SIDM00007	Other Solid Cancers	GDSC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1667
p.P208S	ACH-001550	Skin Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1667
p.P208S	MCC13	skin	COSMIC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1667
p.R188P	SIDM00492	Glioblastoma	GDSC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.R188P	ACH-000269	Brain Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.R188P	AM-38	central nervous system	COSMIC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0556
p.C931Y	ACH-000999	Colon/Colorectal Cancer	CCLE	MSLHVD	LIG_APCC_ABBA_1	916:921	Mutation rewiring degron network	0.0556
p.L971F	ACH-001568	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	966:970	Mutation rewiring degron network	0.3056
p.I190V	ACH-002038	Ovarian Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.1111
p.T258M	TYK-nu	ovary	COSMIC	LTPGQE	DEG_SCF_FBW7_2	265:270	Mutation substituting flanking lysine	0.25
p.A211V	SNU-1040	large intestine	COSMIC	PNSTT	DEG_SPOP_SBC_1	198:202	Mutation rewiring degron network	0.0833

Kaplan plot for ZNF827 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF827

UniProt ID: Q17R98

Entrez ID: 152485

Protein name: Zinc finger protein 827

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF827 in