DegronMD

Uniprot ID: Q17R98

Source protein: Zinc finger protein 827

Source gene: ZNF827

Class: LIG_APCC_ABBA_1

Location: 916:921

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.624

ASA_SCORE: 58.9667

COIL: 0.604

CONS_SCORE: 0.6554

DSS_SCORE: 0.0476

HELIX: 0.0988

FCONS_SCORE: 1.2633

RIG_SCORE: 0.8773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D921E	DO229018	LICA	ICGC	MSLHVD	LIG_APCC_ABBA_1	0.5647
p.E907K	DO220875	MELA	ICGC	MSLHVD	LIG_APCC_ABBA_1	0.0833
p.V910D	DO229446	SKCA	ICGC	MSLHVD	LIG_APCC_ABBA_1	0.1667
p.Q911K	DO229446	SKCA	ICGC	MSLHVD	LIG_APCC_ABBA_1	0.1944
p.C931Y	ACH-000999	Colon/Colorectal Cancer	CCLE	MSLHVD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R98	Zinc finger protein 827	LIG_APCC_ABBA_1	916:921	MSLHVD	APC,CDC20,FZR1	0.624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons