DegronMD

Uniprot ID: Q17R98

Source protein: Zinc finger protein 827

Source gene: ZNF827

Class: DEG_SPOP_SBC_1

Location: 198:202

E3 ligase: SPOP

DEGRON score: 0.9972

ASA_SCORE: 70.64

COIL: 0.8304

CONS_SCORE: 0.29

DSS_SCORE: 0.3449

HELIX: 0.0884

FCONS_SCORE: 0.7778

RIG_SCORE: 0.7448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T201S	TCGA-34-2604	LUSC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.6005
p.T201S	DO26433	LUSC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.6005
p.P198S	TCGA-A5-A0G2	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.6752
p.P198S	DO41235	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.6752
p.R188C	TCGA-B5-A3FA	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.0556
p.R188C	DO52402	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.0556
p.S205N	TCGA-D1-A103	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.25
p.S205N	DO42312	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.25
p.F189I	TCGA-D3-A3C7	SKCM	TCGA	PNSTT	DEG_SPOP_SBC_1	0.0833
p.F189I	DO47569	SKCM	ICGC	PNSTT	DEG_SPOP_SBC_1	0.0833
p.R188S	DO229019	LICA	ICGC	PNSTT	DEG_SPOP_SBC_1	0.0556
p.I190L	SIDM00041	Gastric Carcinoma	GDSC	PNSTT	DEG_SPOP_SBC_1	0.1111
p.I190L	ACH-002306	Gastric Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	0.1111
p.I190L	STS-0421	soft_tissue	COSMIC	PNSTT	DEG_SPOP_SBC_1	0.1111
p.P208S	SIDM00007	Other Solid Cancers	GDSC	PNSTT	DEG_SPOP_SBC_1	0.1667
p.P208S	ACH-001550	Skin Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	0.1667
p.P208S	MCC13	skin	COSMIC	PNSTT	DEG_SPOP_SBC_1	0.1667
p.R188P	SIDM00492	Glioblastoma	GDSC	PNSTT	DEG_SPOP_SBC_1	0.0556
p.R188P	ACH-000269	Brain Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	0.0556
p.R188P	AM-38	central_nervous_system	COSMIC	PNSTT	DEG_SPOP_SBC_1	0.0556
p.I190V	ACH-002038	Ovarian Cancer	CCLE	PNSTT	DEG_SPOP_SBC_1	0.1111
p.A211V	SNU-1040	large_intestine	COSMIC	PNSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R98	Zinc finger protein 827	DEG_SPOP_SBC_1	198:202	PNSTT	SPOP	0.9972	More...
Q9Y4H4	G-protein-signaling modulator 3	DEG_SPOP_SBC_1	26:30	PNSTT	SPOP	0.9281	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons