DegronMD

Uniprot ID: Q9Y4H4

Source protein: G-protein-signaling modulator 3

Source gene: GPSM3

Class: DEG_SPOP_SBC_1

Location: 26:30

E3 ligase: SPOP

DEGRON score: 0.9281

ASA_SCORE: 91.5

COIL: 0.931

CONS_SCORE: 0.7376

DSS_SCORE: 0.8328

HELIX: 0.0362

FCONS_SCORE: 0.834

RIG_SCORE: 0.5226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P24S	TCGA-AA-A02R	COAD	TCGA	PNSTT	DEG_SPOP_SBC_1	0.2778
p.P26S	TCGA-BR-7704	STAD	TCGA	PNSTT	DEG_SPOP_SBC_1	0.6752
p.P26S	DO38360	STAD	ICGC	PNSTT	DEG_SPOP_SBC_1	0.6752
p.E20K	TCGA-D6-A4ZB	HNSC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.1667
p.E20K	TCGA-IR-A3LI	CESC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.1667
p.E20K	DO44400	CESC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.1667
p.E20K	DO44446	HNSC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.1667
p.P17S	TCGA-DF-A2KN	UCEC	TCGA	PNSTT	DEG_SPOP_SBC_1	0.0833
p.P17S	DO223282	UCEC	ICGC	PNSTT	DEG_SPOP_SBC_1	0.0833
p.R34Q	TCGA-WS-AB45	COAD	TCGA	PNSTT	DEG_SPOP_SBC_1	0.2222
p.R34Q	DO51734	COAD	ICGC	PNSTT	DEG_SPOP_SBC_1	0.2222
p.P16A	DO228470	LICA	ICGC	PNSTT	DEG_SPOP_SBC_1	0.0556
p.E21K	DO222527	MELA	ICGC	PNSTT	DEG_SPOP_SBC_1	0.1944
p.F27L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PNSTT	DEG_SPOP_SBC_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R98	Zinc finger protein 827	DEG_SPOP_SBC_1	198:202	PNSTT	SPOP	0.9972	More...
Q9Y4H4	G-protein-signaling modulator 3	DEG_SPOP_SBC_1	26:30	PNSTT	SPOP	0.9281	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons