DegronMD

Uniprot ID: Q17R98

Source protein: Zinc finger protein 827

Source gene: ZNF827

Class: DEG_SCF_FBW7_2

Location: 265:270

E3 ligase: FBXW7

DEGRON score: 0.9888

ASA_SCORE: 75.4333

COIL: 0.814

CONS_SCORE: 0.3253

DSS_SCORE: 0.6376

HELIX: 0.0065

FCONS_SCORE: 0.8564

RIG_SCORE: 0.5673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K259N	TCGA-CN-A63U	HNSC	TCGA	LTPGQE	DEG_SCF_FBW7_2	0.2778
p.K259N	DO44454	HNSC	ICGC	LTPGQE	DEG_SCF_FBW7_2	0.2778
p.S280F	DO229177	LMS	ICGC	LTPGQE	DEG_SCF_FBW7_2	0.0556
p.A275T	DO228839	PBCA	ICGC	LTPGQE	DEG_SCF_FBW7_2	0.1944
p.K258R	SIDM00625	Other Sarcomas	GDSC	LTPGQE	DEG_SCF_FBW7_2	0.25
p.K258R	ACH-000449	Sarcoma	CCLE	LTPGQE	DEG_SCF_FBW7_2	0.25
p.K258R	MES-SA	soft_tissue	COSMIC	LTPGQE	DEG_SCF_FBW7_2	0.25
p.T258M	TYK-nu	ovary	COSMIC	LTPGQE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17R98	Zinc finger protein 827	DEG_SCF_FBW7_2	265:270	LTPGQE	FBXW7	0.9888	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons