DegronMD - Q9NQ75(CASS4)

FUNCTION: Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading. {ECO:0000269|PubMed:18256281}.

GO - Biological processes (BP): actin filament reorganization [GO:0090527]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; positive regulation of cell migration [GO:0030335]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regu... View more >>

GO - Molecular function (MF): protein tyrosine kinase binding [GO:1990782]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R163W	TCGA-CK-6746	COAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	TCGA-EE-A2MS	SKCM	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO7938	COAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO218697	ORCA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO37567	SKCM	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8428
p.R163L	K-562	haematopoietic and lymphoid tissue	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8428
p.P273H	TCGA-91-6828	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P273H	TCGA-97-8172	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P273H	DO26384	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P273H	DO26150	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.S165L	TCGA-E2-A108	BRCA	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7667
p.S165L	DO5731	BRCA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7667
p.R163G	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7568
p.R163G	ACH-000858	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7568
p.R163G	KNS-62	lung	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7568
p.S171F	DO50437	ESAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation blocking phosphorylation signal	0.75
p.R163Q	TCGA-61-2104	OV	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.R163Q	DO31849	OV	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.Y98C	TCGA-BW-A5NO	LIHC	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.7087

Showing 1 to 20 of 205 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASS4

UniProt ID: Q9NQ75

Entrez ID: 57091

Protein name: Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASS4 in