DegronMD - Q9NQ75(CASS4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A264V	TCGA-06-5416	GBM	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264V	TCGA-06-5416	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.A264V	TCGA-BR-8591	STAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264V	TCGA-BR-8591	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.A264V	DO10880	GBM	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264V	DO10880	GBM	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.A264V	DO47973	STAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264V	DO47973	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.S254C	TCGA-13-0920	OV	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.3056
p.S254C	DO28099	OV	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.3056
p.A264G	TCGA-21-1083	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264G	TCGA-21-1083	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.A264G	DO26769	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264G	DO26769	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.F279L	TCGA-37-5819	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.F279L	DO26479	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.K252M	TCGA-39-5011	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation substituting flanking lysine	0.3611
p.K252M	DO27532	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation substituting flanking lysine	0.3611
p.A271S	TCGA-46-3769	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271S	TCGA-46-3769	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271S	DO26590	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271S	DO26590	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.R160I	TCGA-49-6743	LUAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2778
p.R160I	DO26092	LUAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.2778
p.A271P	TCGA-53-A4EZ	LUAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271P	TCGA-53-A4EZ	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271P	DO45319	LUAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271P	DO45319	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271P	SIDM01078	Small Cell Lung Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271P	SIDM01078	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271P	ACH-000790	Lung Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271P	ACH-000790	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271P	SHP-77	lung	COSMIC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271P	SHP-77	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.R163Q	TCGA-61-2104	OV	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.R163Q	DO31849	OV	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7329
p.D175E	TCGA-86-8279	LUAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.D175E	DO24140	LUAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1944
p.P273T	TCGA-91-6828	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7031
p.P273T	DO26150	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7031
p.P273H	TCGA-91-6828	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P273H	TCGA-97-8172	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P273H	DO26384	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P273H	DO26150	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation altering degron motif	0.7694
p.P282L	TCGA-A5-A0G1	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1944
p.P282L	DO42472	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1944
p.E95G	TCGA-A5-A0G3	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.6087
p.E95G	DO44003	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.6087
p.P106H	TCGA-AA-3811	COAD	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.25
p.P106H	DO7962	COAD	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.25
p.R590Q	TCGA-AO-A128	BRCA	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.1111
p.R590Q	DO5326	BRCA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.1111
p.R590Q	DO233888	GACA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.1111
p.K610T	TCGA-AP-A0LM	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation substituting flanking lysine	0.3056
p.K610T	DO43306	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation substituting flanking lysine	0.3056
p.S249P	TCGA-AP-A1DV	UCEC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation blocking phosphorylation signal	0.6111
p.S249P	DO43186	UCEC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation blocking phosphorylation signal	0.6111
p.R105C	TCGA-B5-A0K6	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105C	DO40808	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.K594N	TCGA-B5-A1MX	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation substituting flanking lysine	0.3333
p.K594N	DO41999	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation substituting flanking lysine	0.3333
p.R590W	TCGA-BG-A0VW	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.1111
p.R590W	DO40843	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.1111
p.R85K	TCGA-BH-A0AW	BRCA	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.1111
p.R85K	DO5005	BRCA	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.1111
p.V255I	TCGA-BH-A0DL	BRCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.5965
p.V255I	DO2545	BRCA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.5965
p.V255I	SIDM01435	Hepatocellular Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.5965
p.V255I	ACH-000686	Liver Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.5965
p.Y98C	TCGA-BW-A5NO	LIHC	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.7087
p.Y98C	DO52171	LIHC	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.7087
p.K610E	TCGA-CA-6717	COAD	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation substituting flanking lysine	0.3056
p.K610E	DO8264	COAD	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation substituting flanking lysine	0.3056
p.R163W	TCGA-CK-6746	COAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	TCGA-EE-A2MS	SKCM	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO7938	COAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO218697	ORCA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.R163W	DO37567	SKCM	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8634
p.P602T	TCGA-D3-A3C8	SKCM	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation altering degron motif	0.7031
p.P602T	DO47636	SKCM	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation altering degron motif	0.7031
p.S262G	TCGA-D8-A1J8	BRCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.6993
p.S262G	DO1269	BRCA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.6993
p.E96D	TCGA-DF-A2KU	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.5647
p.E96D	DO223286	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.5647
p.P615H	TCGA-DJ-A2QB	THCA	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.0556
p.P615H	DO39421	THCA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.0556
p.S165L	TCGA-E2-A108	BRCA	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7667
p.S165L	DO5731	BRCA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7667
p.C608S	TCGA-EE-A29D	SKCM	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.25
p.C608S	DO38123	SKCM	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.25
p.E596D	TCGA-EO-A22R	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.2778
p.E596D	TCGA-UZ-A9PO	KIRP	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.2778
p.E596D	DO219704	KIRP	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.2778
p.E596D	DO42713	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.2778
p.L84M	TCGA-ER-A19Q	SKCM	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.0833
p.L84M	DO47497	SKCM	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.0833
p.E95Q	TCGA-F7-8298	HNSC	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.5633
p.E95Q	DO14958	HNSC	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.5633
p.E88K	TCGA-FS-A1Z4	SKCM	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.1944
p.E88K	DO37462	SKCM	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.1944
p.P615L	TCGA-GN-A267	SKCM	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.0556
p.P615L	DO220851	MELA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.0556
p.P615L	DO38147	SKCM	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.0556
p.A271T	TCGA-HF-7132	STAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271T	TCGA-HF-7132	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271T	DO48682	LIRI	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271T	DO48682	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271T	DO38214	STAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271T	DO38214	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271V	TCGA-LH-A9QB	SKCM	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271V	TCGA-LH-A9QB	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.A271V	DO51266	SKCM	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.0833
p.A271V	DO51266	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.2778
p.P107H	TCGA-NJ-A4YQ	LUAD	TCGA	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2222
p.P107H	DO218944	LUAD	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2222
p.E266G	TCGA-S8-A6BV	ESCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2222
p.E266G	TCGA-S8-A6BV	ESCA	TCGA	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1389
p.S171F	DO50437	ESAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation blocking phosphorylation signal	0.75
p.T157M	DO234162	ESAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation blocking phosphorylation signal	0.6389
p.R105H	DO223024	ESCA	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105H	SIDM00217	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105H	SIDM00839	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105H	ACH-000950	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105H	ACH-000999	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105H	SNU-1040	large intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.R105H	LoVo	large intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.P167S	DO233766	GACA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5641
p.P167S	SIDM00282	Colorectal Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5641
p.P167S	ACH-000998	Colon/Colorectal Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5641
p.P167S	CW-2	large intestine	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5641
p.F588L	DO233769	GACA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.0556
p.A264S	DO228976	LICA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2778
p.A264S	DO228976	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.0833
p.G285V	DO229037	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1111
p.A154T	DO50970	LICA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1111
p.E266K	DO222837	MELA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation rewiring degron network	0.2222
p.E266K	DO222837	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1389
p.L103P	DO218012	ORCA	ICGC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation altering degron motif	0.6471
p.Y174H	DO51483	PACA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation blocking phosphorylation signal	0.6667
p.E593K	SIDM02064	Colorectal Carcinoma	GDSC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation rewiring degron network	0.1944
p.T168I	SIDM00570	Gastric Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00434	Plasma Cell Myeloma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01040	Ovarian Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00281	Other Solid Cancers	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00251	Gastric Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00375	Head and Neck Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00560	Gastric Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00381	Cervical Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01439	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01659	Kidney Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01569	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01347	Ovarian Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01588	Endometrial Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01391	Neuroblastoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM01442	Glioma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.T168I	SIDM00162	Biliary Tract Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.5966
p.R163L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8428
p.R163L	K-562	haematopoietic and lymphoid tissue	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.8428
p.A604G	SIDM00491	Thyroid Gland Carcinoma	GDSC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation altering degron motif	0.6429
p.A604G	ASH-3	thyroid	COSMIC	VQLTPNAE	DEG_SCF_FBW7_2	598:605	Mutation altering degron motif	0.6429
p.V176M	SIDM00533	Pancreatic Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM00235	Kidney Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM00585	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM00469	Pancreatic Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM00566	Oral Cavity Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM01695	Acute Myeloid Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	SIDM01472	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000118	Pancreatic Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000166	Leukemia	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000189	Kidney Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000237	Ovarian Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000261	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000320	Pancreatic Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000408	Esophageal Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000419	Myeloma	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000471	Liver Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000480	Liver Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-000705	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-001113	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-001541	Myeloma	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-001608	Brain Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-001625	Head and Neck Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-002055	Lymphoma	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-002122	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.V176M	ACH-002156	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.S284T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	273:277	Mutation rewiring degron network	0.1389
p.R163G	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7568
p.R163G	ACH-000858	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7568
p.R163G	KNS-62	lung	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation altering degron motif	0.7568
p.P259T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.7031
p.P259T	ACH-000945	Lung Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.7031
p.P259T	NCI-H650	lung	COSMIC	VRNTPLTS	DEG_SCF_FBW7_1	255:262	Mutation altering degron motif	0.7031
p.P91L	SIDM00837	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.P91L	ACH-000958	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.P91L	SW48	large intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	93:103	Mutation rewiring degron network	0.2778
p.L156V	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.L156V	ACH-000875	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.L156V	NCI-H2347	lung	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.1667
p.H180Y	ACH-001838	Bile Duct Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	162:170	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CASS4

UniProt ID: Q9NQ75

Entrez ID: 57091

Protein name: Cas scaffolding protein family member 4 (HEF-like protein) (HEF1-EFS-p130Cas-like protein) (HEPL)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CASS4 in