DegronMD

Uniprot ID: Q9NQ75

Source protein: Cas scaffolding protein family member 4

Source gene: CASS4

Class: DEG_APCC_DBOX_1

Location: 162:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9847

ASA_SCORE: 82.4667

COIL: 0.889

CONS_SCORE: 0.2499

DSS_SCORE: 0.3712

HELIX: 0.0743

FCONS_SCORE: 0.6639

RIG_SCORE: 0.7099

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R160I	TCGA-49-6743	LUAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	0.2778
p.R160I	DO26092	LUAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.2778
p.R163Q	TCGA-61-2104	OV	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	0.7329
p.R163Q	DO31849	OV	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.7329
p.D175E	TCGA-86-8279	LUAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	0.1944
p.D175E	DO24140	LUAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.1944
p.R163W	TCGA-CK-6746	COAD	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	0.8634
p.R163W	TCGA-EE-A2MS	SKCM	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	0.8634
p.R163W	DO7938	COAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.8634
p.R163W	DO218697	ORCA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.8634
p.R163W	DO37567	SKCM	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.8634
p.S165L	TCGA-E2-A108	BRCA	TCGA	VRASLPTLP	DEG_APCC_DBOX_1	0.7667
p.S165L	DO5731	BRCA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.7667
p.S171F	DO50437	ESAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.75
p.T157M	DO234162	ESAD	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.6389
p.P167S	DO233766	GACA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.5641
p.P167S	SIDM00282	Colorectal Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5641
p.P167S	ACH-000998	Colon/Colorectal Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.5641
p.P167S	CW-2	large_intestine	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	0.5641
p.A154T	DO50970	LICA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.1111
p.Y174H	DO51483	PACA	ICGC	VRASLPTLP	DEG_APCC_DBOX_1	0.6667
p.T168I	SIDM00570	Gastric Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00434	Plasma Cell Myeloma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01040	Ovarian Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00281	Other Solid Cancers	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00251	Gastric Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00375	Head and Neck Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00560	Gastric Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00451	T-Lymphoblastic Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00381	Cervical Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01439	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01659	Kidney Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01569	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01347	Ovarian Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01588	Endometrial Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01391	Neuroblastoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM01442	Glioma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.T168I	SIDM00162	Biliary Tract Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.5966
p.R163L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.8428
p.R163L	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	0.8428
p.V176M	SIDM00533	Pancreatic Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM00235	Kidney Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM00585	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM00469	Pancreatic Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM00566	Oral Cavity Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM01695	Acute Myeloid Leukemia	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	SIDM01472	Hepatocellular Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000118	Pancreatic Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000166	Leukemia	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000189	Kidney Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000237	Ovarian Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000261	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000320	Pancreatic Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000408	Esophageal Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000419	Myeloma	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000471	Liver Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000480	Liver Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-000705	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-001113	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-001541	Myeloma	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-001608	Brain Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-001625	Head and Neck Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-002055	Lymphoma	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-002122	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.V176M	ACH-002156	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.R163G	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.7568
p.R163G	ACH-000858	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.7568
p.R163G	KNS-62	lung	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	0.7568
p.L156V	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.L156V	ACH-000875	Lung Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.L156V	NCI-H2347	lung	COSMIC	VRASLPTLP	DEG_APCC_DBOX_1	0.1667
p.H180Y	ACH-001838	Bile Duct Cancer	CCLE	VRASLPTLP	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRASLPTLP

Degron related mutations and impact score

Drug responses associated with CASS4 mutations

All proteins holding degron of VRASLPTLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ75	Cas scaffolding protein family member 4	DEG_APCC_DBOX_1	162:170	VRASLPTLP	APC,CDC20,FZR1	0.9847	More...