DegronMD

Uniprot ID: Q9NQ75

Source protein: Cas scaffolding protein family member 4

Source gene: CASS4

Class: DEG_SCF_FBW7_2

Location: 598:605

E3 ligase: FBXW7

DEGRON score: 0.6996

ASA_SCORE: 87.9875

COIL: 0.7559

CONS_SCORE: 0.2299

DSS_SCORE: 0.3648

HELIX: 0.2026

FCONS_SCORE: 0.582

RIG_SCORE: 0.7801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R590Q	TCGA-AO-A128	BRCA	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.1111
p.R590Q	DO5326	BRCA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.1111
p.R590Q	DO233888	GACA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.1111
p.K610T	TCGA-AP-A0LM	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.3056
p.K610T	DO43306	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.3056
p.K594N	TCGA-B5-A1MX	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.3333
p.K594N	DO41999	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.3333
p.R590W	TCGA-BG-A0VW	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.1111
p.R590W	DO40843	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.1111
p.K610E	TCGA-CA-6717	COAD	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.3056
p.K610E	DO8264	COAD	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.3056
p.P602T	TCGA-D3-A3C8	SKCM	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.7031
p.P602T	DO47636	SKCM	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.7031
p.P615H	TCGA-DJ-A2QB	THCA	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.0556
p.P615H	DO39421	THCA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.0556
p.C608S	TCGA-EE-A29D	SKCM	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.25
p.C608S	DO38123	SKCM	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.25
p.E596D	TCGA-EO-A22R	UCEC	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.2778
p.E596D	TCGA-UZ-A9PO	KIRP	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.2778
p.E596D	DO219704	KIRP	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.2778
p.E596D	DO42713	UCEC	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.2778
p.P615L	TCGA-GN-A267	SKCM	TCGA	VQLTPNAE	DEG_SCF_FBW7_2	0.0556
p.P615L	DO220851	MELA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.0556
p.P615L	DO38147	SKCM	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.0556
p.F588L	DO233769	GACA	ICGC	VQLTPNAE	DEG_SCF_FBW7_2	0.0556
p.E593K	SIDM02064	Colorectal Carcinoma	GDSC	VQLTPNAE	DEG_SCF_FBW7_2	0.1944
p.A604G	SIDM00491	Thyroid Gland Carcinoma	GDSC	VQLTPNAE	DEG_SCF_FBW7_2	0.6429
p.A604G	ASH-3	thyroid	COSMIC	VQLTPNAE	DEG_SCF_FBW7_2	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ75	Cas scaffolding protein family member 4	DEG_SCF_FBW7_2	598:605	VQLTPNAE	FBXW7	0.6996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQLTPNAE

Degron related mutations and impact score

Drug responses associated with CASS4 mutations

All proteins holding degron of VQLTPNAE