DegronMD

Uniprot ID: Q9NQ75

Source protein: Cas scaffolding protein family member 4

Source gene: CASS4

Class: DEG_SCF_FBW7_1

Location: 255:262

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 81.0625

COIL: 0.8409

CONS_SCORE: 0.3085

DSS_SCORE: 0.5779

HELIX: 0.053

FCONS_SCORE: 0.7379

RIG_SCORE: 0.6992

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A264V	TCGA-06-5416	GBM	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264V	TCGA-BR-8591	STAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264V	DO10880	GBM	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264V	DO47973	STAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.S254C	TCGA-13-0920	OV	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.3056
p.S254C	DO28099	OV	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.3056
p.A264G	TCGA-21-1083	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264G	DO26769	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.K252M	TCGA-39-5011	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.3611
p.K252M	DO27532	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.3611
p.A271S	TCGA-46-3769	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271S	DO26590	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271P	TCGA-53-A4EZ	LUAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271P	DO45319	LUAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271P	SIDM01078	Small Cell Lung Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271P	ACH-000790	Lung Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271P	SHP-77	lung	COSMIC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.S249P	TCGA-AP-A1DV	UCEC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.6111
p.S249P	DO43186	UCEC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.6111
p.V255I	TCGA-BH-A0DL	BRCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.V255I	DO2545	BRCA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.V255I	SIDM01435	Hepatocellular Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.V255I	ACH-000686	Liver Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.S262G	TCGA-D8-A1J8	BRCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.6993
p.S262G	DO1269	BRCA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.6993
p.A271T	TCGA-HF-7132	STAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271T	DO48682	LIRI	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271T	DO38214	STAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271V	TCGA-LH-A9QB	SKCM	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.A271V	DO51266	SKCM	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.0833
p.E266G	TCGA-S8-A6BV	ESCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2222
p.A264S	DO228976	LICA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.E266K	DO222837	MELA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2222
p.P259T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	0.7031
p.P259T	ACH-000945	Lung Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	0.7031
p.P259T	NCI-H650	lung	COSMIC	VRNTPLTS	DEG_SCF_FBW7_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRNTPLTS

Degron related mutations and impact score

Drug responses associated with CASS4 mutations

All proteins holding degron of VRNTPLTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ75	Cas scaffolding protein family member 4	DEG_SCF_FBW7_1	255:262	VRNTPLTS	FBXW7	0.9987	More...