DegronMD

Uniprot ID: Q9NQ75

Source protein: Cas scaffolding protein family member 4

Source gene: CASS4

Class: DEG_SCF_FBW7_1

Location: 255:262

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 81.0625

COIL: 0.8409

CONS_SCORE: 0.3085

DSS_SCORE: 0.5779

HELIX: 0.053

FCONS_SCORE: 0.7379

RIG_SCORE: 0.6992

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P259T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	0.7031
p.P259T	ACH-000945	Lung Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	0.7031
p.P259T	NCI-H650	lung	COSMIC	VRNTPLTS	DEG_SCF_FBW7_1	0.7031
p.S262G	TCGA-D8-A1J8	BRCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.6993
p.S262G	DO1269	BRCA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.6993
p.S249P	TCGA-AP-A1DV	UCEC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.6111
p.S249P	DO43186	UCEC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.6111
p.V255I	TCGA-BH-A0DL	BRCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.V255I	DO2545	BRCA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.V255I	SIDM01435	Hepatocellular Carcinoma	GDSC	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.V255I	ACH-000686	Liver Cancer	CCLE	VRNTPLTS	DEG_SCF_FBW7_1	0.5965
p.K252M	TCGA-39-5011	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.3611
p.K252M	DO27532	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.3611
p.S254C	TCGA-13-0920	OV	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.3056
p.S254C	DO28099	OV	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.3056
p.A264V	TCGA-06-5416	GBM	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264V	TCGA-BR-8591	STAD	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264V	DO10880	GBM	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264V	DO47973	STAD	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264G	TCGA-21-1083	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264G	DO26769	LUSC	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.A264S	DO228976	LICA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2778
p.E266G	TCGA-S8-A6BV	ESCA	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.2222
p.E266K	DO222837	MELA	ICGC	VRNTPLTS	DEG_SCF_FBW7_1	0.2222
p.A271S	TCGA-46-3769	LUSC	TCGA	VRNTPLTS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ75	Cas scaffolding protein family member 4	DEG_SCF_FBW7_1	255:262	VRNTPLTS	FBXW7	0.9987	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons