DegronMD

Uniprot ID: Q9NQ75

Source protein: Cas scaffolding protein family member 4

Source gene: CASS4

Class: DEG_COP1_1

Location: 93:103

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 87.1455

COIL: 0.8357

CONS_SCORE: 0.4687

DSS_SCORE: 0.6631

HELIX: 0.1327

FCONS_SCORE: 1.4574

RIG_SCORE: 0.6624

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E95G	TCGA-A5-A0G3	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.6087
p.E95G	DO44003	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.6087
p.P106H	TCGA-AA-3811	COAD	TCGA	SSEETYQVPTL	DEG_COP1_1	0.25
p.P106H	DO7962	COAD	ICGC	SSEETYQVPTL	DEG_COP1_1	0.25
p.R105C	TCGA-B5-A0K6	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105C	DO40808	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R85K	TCGA-BH-A0AW	BRCA	TCGA	SSEETYQVPTL	DEG_COP1_1	0.1111
p.R85K	DO5005	BRCA	ICGC	SSEETYQVPTL	DEG_COP1_1	0.1111
p.Y98C	TCGA-BW-A5NO	LIHC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.7087
p.Y98C	DO52171	LIHC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.7087
p.E96D	TCGA-DF-A2KU	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.5647
p.E96D	DO223286	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.5647
p.L84M	TCGA-ER-A19Q	SKCM	TCGA	SSEETYQVPTL	DEG_COP1_1	0.0833
p.L84M	DO47497	SKCM	ICGC	SSEETYQVPTL	DEG_COP1_1	0.0833
p.E95Q	TCGA-F7-8298	HNSC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.5633
p.E95Q	DO14958	HNSC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.5633
p.E88K	TCGA-FS-A1Z4	SKCM	TCGA	SSEETYQVPTL	DEG_COP1_1	0.1944
p.E88K	DO37462	SKCM	ICGC	SSEETYQVPTL	DEG_COP1_1	0.1944
p.P107H	TCGA-NJ-A4YQ	LUAD	TCGA	SSEETYQVPTL	DEG_COP1_1	0.2222
p.P107H	DO218944	LUAD	ICGC	SSEETYQVPTL	DEG_COP1_1	0.2222
p.R105H	DO223024	ESCA	ICGC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	SIDM00217	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	SIDM00839	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	ACH-000950	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	ACH-000999	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	SNU-1040	large_intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	LoVo	large_intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.L103P	DO218012	ORCA	ICGC	SSEETYQVPTL	DEG_COP1_1	0.6471
p.P91L	SIDM00837	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.P91L	ACH-000958	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	0.2778
p.P91L	SW48	large_intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSEETYQVPTL

Degron related mutations and impact score

Drug responses associated with CASS4 mutations

All proteins holding degron of SSEETYQVPTL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ75	Cas scaffolding protein family member 4	DEG_COP1_1	93:103	SSEETYQVPTL	COP1	0.9995	More...