DegronMD

Uniprot ID: Q9NQ75

Source protein: Cas scaffolding protein family member 4

Source gene: CASS4

Class: DEG_COP1_1

Location: 93:103

E3 ligase: COP1

DEGRON score: 0.9995

ASA_SCORE: 87.1455

COIL: 0.8357

CONS_SCORE: 0.4687

DSS_SCORE: 0.6631

HELIX: 0.1327

FCONS_SCORE: 1.4574

RIG_SCORE: 0.6624

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y98C	TCGA-BW-A5NO	LIHC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.7087
p.Y98C	DO52171	LIHC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.7087
p.L103P	DO218012	ORCA	ICGC	SSEETYQVPTL	DEG_COP1_1	0.6471
p.E95G	TCGA-A5-A0G3	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.6087
p.E95G	DO44003	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.6087
p.E96D	TCGA-DF-A2KU	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.5647
p.E96D	DO223286	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.5647
p.E95Q	TCGA-F7-8298	HNSC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.5633
p.E95Q	DO14958	HNSC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.5633
p.R105C	TCGA-B5-A0K6	UCEC	TCGA	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105C	DO40808	UCEC	ICGC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	DO223024	ESCA	ICGC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	SIDM00217	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	SIDM00839	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	ACH-000950	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	ACH-000999	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	SNU-1040	large_intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.R105H	LoVo	large_intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.P91L	SIDM00837	Colorectal Carcinoma	GDSC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.P91L	ACH-000958	Colon/Colorectal Cancer	CCLE	SSEETYQVPTL	DEG_COP1_1	0.2778
p.P91L	SW48	large_intestine	COSMIC	SSEETYQVPTL	DEG_COP1_1	0.2778
p.P106H	TCGA-AA-3811	COAD	TCGA	SSEETYQVPTL	DEG_COP1_1	0.25
p.P106H	DO7962	COAD	ICGC	SSEETYQVPTL	DEG_COP1_1	0.25
p.P107H	TCGA-NJ-A4YQ	LUAD	TCGA	SSEETYQVPTL	DEG_COP1_1	0.2222
p.P107H	DO218944	LUAD	ICGC	SSEETYQVPTL	DEG_COP1_1	0.2222

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ75	Cas scaffolding protein family member 4	DEG_COP1_1	93:103	SSEETYQVPTL	COP1	0.9995	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons