DegronMD - Q8WUI4(HDAC7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R63H	TCGA-AA-A01R	COAD	TCGA	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.1389
p.R63H	TCGA-AA-A01R	COAD	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.2222
p.R63H	TCGA-NH-A5IV	COAD	TCGA	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.1389
p.R63H	TCGA-NH-A5IV	COAD	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.2222
p.R66H	TCGA-AJ-A3BH	UCEC	TCGA	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.0556
p.R66H	TCGA-AJ-A3BH	UCEC	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.3056
p.R66H	DO41638	UCEC	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.0556
p.R66H	DO41638	UCEC	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.3056
p.K199N	TCGA-AX-A2HD	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6918
p.K199N	DO42608	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation altering degron motif	0.6918
p.R190H	TCGA-AY-A8YK	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.R190H	SIDM00217	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.R190H	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0833
p.L76M	TCGA-CM-6162	COAD	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation substituting flanking lysine	0.3611
p.L76M	DO8479	COAD	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation substituting flanking lysine	0.3611
p.S194F	TCGA-FW-A3R5	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.R80H	DO227987	COCA	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.1389
p.A496S	DO233707	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	505:509	Mutation rewiring degron network	0.0833
p.A40T	DO15398	HNSC	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.0556
p.A40T	DO51854	LGG	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.0556
p.A40T	DO36881	READ	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.0556
p.A40T	DO51761	STAD	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.0556
p.T193N	DO228976	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1667
p.A505D	DO229031	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	505:509	Mutation altering degron motif	0.7793
p.P204H	DO45115	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.3056
p.T52M	DO27667	LUSC	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation altering degron motif	0.7423
p.R47Q	DO49419	PACA	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.25
p.R47K	DO232224	PBCA	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.25
p.S197F	DO46847	RECA	ICGC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.K72N	DO37515	SKCM	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation altering degron motif	0.5806
p.P45S	DO229272	THCA	ICGC	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.1944
p.A206T	DO41871	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.25
p.R80C	SIDM01165	Pancreatic Carcinoma	GDSC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.1389
p.V82M	SIDM00874	Breast Carcinoma	GDSC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.0833
p.V43M	ACH-000223	Breast Cancer	CCLE	MDTPMPE	DEG_SCF_FBW7_2	50:56	Mutation rewiring degron network	0.1389
p.V80I	ACH-000301	Leukemia	CCLE	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.1389
p.V80I	LAMA-84	haematopoietic and lymphoid tissue	COSMIC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.1389
p.L194F	ACH-000347	Pancreatic Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.L194F	QGP-1	pancreas	COSMIC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1944
p.R77Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	RQLLHKD	LIG_APCC_ABBAyCdc20_2	67:73	Mutation rewiring degron network	0.2222
p.P205L	ACH-001201	Brain Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2778
p.R211W	HuH-7	liver	COSMIC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.1111
p.R189W	HuH-7	liver	COSMIC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.0556
p.R207H	SNU-1040	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	199:203	Mutation rewiring degron network	0.2222

Kaplan plot for HDAC7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HDAC7

UniProt ID: Q8WUI4

Entrez ID: 51564

Protein name: Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for HDAC7 in