DegronMD

Uniprot ID: Q8WUI4

Source protein: Histone deacetylase 7

Source gene: HDAC7

Class: DEG_SCF_FBW7_2

Location: 50:56

E3 ligase: FBXW7

DEGRON score: 0.9698

ASA_SCORE: 113.4429

COIL: 0.7964

CONS_SCORE: 0.3508

DSS_SCORE: 0.6283

HELIX: 0.1959

FCONS_SCORE: 0.9616

RIG_SCORE: 0.6837

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63H	TCGA-AA-A01R	COAD	TCGA	MDTPMPE	DEG_SCF_FBW7_2	0.1389
p.R63H	TCGA-NH-A5IV	COAD	TCGA	MDTPMPE	DEG_SCF_FBW7_2	0.1389
p.R66H	TCGA-AJ-A3BH	UCEC	TCGA	MDTPMPE	DEG_SCF_FBW7_2	0.0556
p.R66H	DO41638	UCEC	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.0556
p.A40T	DO15398	HNSC	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.0556
p.A40T	DO51854	LGG	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.0556
p.A40T	DO36881	READ	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.0556
p.A40T	DO51761	STAD	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.0556
p.T52M	DO27667	LUSC	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.7423
p.R47Q	DO49419	PACA	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.25
p.R47K	DO232224	PBCA	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.25
p.P45S	DO229272	THCA	ICGC	MDTPMPE	DEG_SCF_FBW7_2	0.1944
p.V43M	ACH-000223	Breast Cancer	CCLE	MDTPMPE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUI4	Histone deacetylase 7	DEG_SCF_FBW7_2	50:56	MDTPMPE	FBXW7	0.9698	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons