DegronMD

Uniprot ID: Q8WUI4

Source protein: Histone deacetylase 7

Source gene: HDAC7

Class: LIG_APCC_ABBAyCdc20_2

Location: 67:73

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6151

ASA_SCORE: 108.6714

COIL: 0.5187

CONS_SCORE: 0.3606

DSS_SCORE: 0.5623

HELIX: 0.4661

FCONS_SCORE: 0.9818

RIG_SCORE: 0.7564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63H	TCGA-AA-A01R	COAD	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R63H	TCGA-NH-A5IV	COAD	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R66H	TCGA-AJ-A3BH	UCEC	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R66H	DO41638	UCEC	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L76M	TCGA-CM-6162	COAD	TCGA	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.3611
p.L76M	DO8479	COAD	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.3611
p.R80H	DO227987	COCA	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.K72N	DO37515	SKCM	ICGC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.5806
p.R80C	SIDM01165	Pancreatic Carcinoma	GDSC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V82M	SIDM00874	Breast Carcinoma	GDSC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V80I	ACH-000301	Leukemia	CCLE	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.V80I	LAMA-84	haematopoietic_and_lymphoid_tissue	COSMIC	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R77Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	RQLLHKD	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WUI4	Histone deacetylase 7	LIG_APCC_ABBAyCdc20_2	67:73	RQLLHKD	APC,CDC20,FZR1	0.6151	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons