DegronMD - Q5TF21(SOGA3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S222Y	TCGA-21-1083	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.712
p.S222Y	DO26769	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.712
p.S219P	TCGA-2V-A95S	LIHC	TCGA	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.5641
p.S219P	DO223911	LIHC	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.5641
p.A801V	TCGA-4Z-AA7O	BLCA	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2222
p.A801V	DO51865	BLCA	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2222
p.L792F	TCGA-67-3771	LUAD	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.6981
p.L792F	DO25797	LUAD	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.6981
p.R796L	TCGA-77-8154	LUSC	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7316
p.R796L	DO27224	LUSC	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7316
p.D782N	TCGA-AJ-A3OK	UCEC	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.0556
p.D782N	TCGA-EE-A20C	SKCM	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.0556
p.D782N	DO47665	SKCM	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.0556
p.D782N	DO43602	UCEC	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.0556
p.G224D	TCGA-BR-6452	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.G224D	DO38404	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2778
p.G803W	TCGA-D1-A15X	UCEC	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1667
p.G803W	DO43274	UCEC	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1667
p.T793M	TCGA-EE-A2GO	SKCM	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7423
p.T793M	DO37823	SKCM	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7423
p.T793M	SIDM00537	Colorectal Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7423
p.T793M	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7423
p.T793M	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7423
p.T793M	GP5d	large intestine	COSMIC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation altering degron motif	0.7423
p.R790C	TCGA-EE-A3AH	SKCM	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790C	TCGA-XK-AAIW	PRAD	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790C	DO222635	MELA	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790C	DO51407	PRAD	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790C	DO37074	READ	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790C	DO37443	SKCM	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790H	TCGA-EY-A1GU	UCEC	TCGA	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.R790H	DO41518	UCEC	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.S222F	DO222857	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7982
p.Y799D	DO234254	ESAD	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2778
p.I789F	DO222444	ESCA	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.25
p.P227T	DO233262	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.G211R	DO233649	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.P804T	DO229018	LICA	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1389
p.R787S	DO229029	LICA	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1944
p.R787S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1944
p.R787S	H513	pleura	COSMIC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1944
p.N788K	DO229037	LICA	ICGC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.2222
p.T226A	DO228253	MALY	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.E212G	DO229140	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.E212G	DO229144	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.E212G	DO229151	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.E212G	DO229180	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.E212G	DO229195	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.E212G	DO229121	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.E212G	DO229088	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1667
p.A214G	DO229188	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.A214G	DO229204	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.R787C	SIDM02041	Colorectal Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1944
p.G803R	SIDM02030	Colorectal Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1667
p.S231N	SIDM00425	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.S231N	ACH-000663	Ovarian Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.P218L	SIDM00007	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7582
p.P218L	ACH-001550	Skin Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7582
p.P218L	MCC13	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7582
p.G210S	SIDM00272	Breast Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.W805R	SIDM00675	Breast Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1111
p.W805R	ACH-000276	Breast Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1111
p.W805R	HCC38	breast	COSMIC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1111
p.P227A	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.P227A	ACH-000869	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.P227A	NCI-H1568	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.E785D	SIDM01394	Kidney Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1389
p.E785D	ACH-000907	Kidney Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	792:797	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOGA3

UniProt ID: Q5TF21

Entrez ID: 387104

Protein name: Protein SOGA3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOGA3 in