DegronMD

Uniprot ID: Q5TF21

Source protein: Protein SOGA3

Source gene: SOGA3

Class: DEG_SCF_FBW7_1

Location: 792:797

E3 ligase: FBXW7

DEGRON score: 0.5718

ASA_SCORE: 100.5667

COIL: 0.887

CONS_SCORE: 0.6357

DSS_SCORE: 0.5353

HELIX: 0.0835

FCONS_SCORE: 1.0301

RIG_SCORE: 0.7369

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A801V	TCGA-4Z-AA7O	BLCA	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.2222
p.A801V	DO51865	BLCA	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2222
p.L792F	TCGA-67-3771	LUAD	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.6981
p.L792F	DO25797	LUAD	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.6981
p.R796L	TCGA-77-8154	LUSC	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.7316
p.R796L	DO27224	LUSC	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.7316
p.D782N	TCGA-AJ-A3OK	UCEC	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.0556
p.D782N	TCGA-EE-A20C	SKCM	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.0556
p.D782N	DO47665	SKCM	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.0556
p.D782N	DO43602	UCEC	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.0556
p.G803W	TCGA-D1-A15X	UCEC	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.1667
p.G803W	DO43274	UCEC	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.1667
p.T793M	TCGA-EE-A2GO	SKCM	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.7423
p.T793M	DO37823	SKCM	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.7423
p.T793M	SIDM00537	Colorectal Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	0.7423
p.T793M	ACH-000982	Colon/Colorectal Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	0.7423
p.T793M	ACH-001345	Colon/Colorectal Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	0.7423
p.T793M	GP5d	large_intestine	COSMIC	LTPTRS	DEG_SCF_FBW7_1	0.7423
p.R790C	TCGA-EE-A3AH	SKCM	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790C	TCGA-XK-AAIW	PRAD	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790C	DO222635	MELA	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790C	DO51407	PRAD	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790C	DO37074	READ	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790C	DO37443	SKCM	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790H	TCGA-EY-A1GU	UCEC	TCGA	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.R790H	DO41518	UCEC	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.Y799D	DO234254	ESAD	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2778
p.I789F	DO222444	ESCA	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.25
p.P804T	DO229018	LICA	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.1389
p.R787S	DO229029	LICA	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.1944
p.R787S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	0.1944
p.R787S	H513	pleura	COSMIC	LTPTRS	DEG_SCF_FBW7_1	0.1944
p.N788K	DO229037	LICA	ICGC	LTPTRS	DEG_SCF_FBW7_1	0.2222
p.R787C	SIDM02041	Colorectal Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	0.1944
p.G803R	SIDM02030	Colorectal Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	0.1667
p.W805R	SIDM00675	Breast Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	0.1111
p.W805R	ACH-000276	Breast Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	0.1111
p.W805R	HCC38	breast	COSMIC	LTPTRS	DEG_SCF_FBW7_1	0.1111
p.E785D	SIDM01394	Kidney Carcinoma	GDSC	LTPTRS	DEG_SCF_FBW7_1	0.1389
p.E785D	ACH-000907	Kidney Cancer	CCLE	LTPTRS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPTRS

Degron related mutations and impact score

Drug responses associated with SOGA3 mutations

All proteins holding degron of LTPTRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TF21	Protein SOGA3	DEG_SCF_FBW7_1	792:797	LTPTRS	FBXW7	0.5718	More...